Vonazol 50 mg (Tablet)
Unit Price: ৳ 40.00 (1 x 10: ৳ 400.00)
Strip Price: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Voriconazole |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of invasive aspergillosis
- Treatment of candidemia
- Treatment of disseminated candidiasis
- Treatment of esophageal candidiasis
- Treatment of serious infections caused by Scedosporium apiospermum and Fusarium Species
- Treatment for patients intolerant of, or refractory to other therapy
Pharmacology
- Mechanism of action involves binding and inhibiting ergosterol synthesis
- Inhibition of CYP450-dependent 14-alpha sterol demethylase
- Depletion of ergosterol in fungal cell membrane
Dosage & Administration
- Oral administration at least one hour before or after a meal
- Different dosage regimens based on body weight
- Specific dosage for invasive aspergillosis, candidemia, Scedosporiosis, and Fusariosis
- Reconstitution instructions for suspension
Interaction
- Dosage adjustments when co-administered with CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
- Potential increase in concentrations and activity of other drugs that are CYP3A4, CYP2C9, and CYP2C19 substrates
- Increased maintenance dosage with co-administration of Phenytoin or Efavirenz
Contraindications
- Known hypersensitivity to Voriconazole or any other components of the drug
- Co-administration contraindicated with specific drugs due to risk of serious adverse reactions or loss of efficacy
Side Effects
- Abdominal pain
- Anemia
- Blurred vision
- Headache
- Chest pain
- Nausea
- Diarrhea
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Use during pregnancy only if potential benefit justifies the potential risk to the fetus
Precautions & Warnings
- Careful assessment of benefit-risk balance for treatment or prophylaxis exceeding 180 days
- Reported association with long-term treatment and squamous cell carcinoma of the skin (SCC)
Use in Special Populations
- Efficacy not established for children under 12 years of age
Overdose Effects
- No available data on overdose effects
Therapeutic Class
- Belongs to the category of other antifungal preparations
Reconstitution
- Instructions for reconstituting suspension
- Storage conditions for reconstituted suspension
Storage Conditions
- Keep out of reach of children
- Store in a dry place below 25°C, protected from light
- Specific storage requirements for Vonazol powder for suspension