Fexocold 120 mg (Tablet)

Indications

• Relief of symptoms associated with seasonal and perennial allergic rhinitis
• Relief of symptoms associated with chronic idiopathic urticaria
• Improvement of health-related quality of life and work/activity productivity

Pharmacology

• Fexofenadine considered an 'inverse agonist' of the H1 receptor
• Selective affinity for H1 receptors
• No evidence of antidopaminergic, antiserotonergic, or anticholinergic activity

Dosage & Administration

• Different dosage for adults and children
• In case of impaired renal function, adjust dosage accordingly

Interaction

• Coadministration with erythromycin or ketoconazole can increase fexofenadine level in plasma
• No interaction between fexofenadine and omeprazole
• Antacid containing aluminium and magnesium hydroxide can reduce bioavailability

Contraindications

• Known hypersensitivity to Fexofenadine Hydrochloride or any of its ingredients

Side Effects

• Common undesirable effects include headache, drowsiness, nausea, and fatigue
• Uncommon reactions can include hypersensitivity reactions and tachycardia

Pregnancy & Lactation

• Limited data on use during pregnancy, not recommended unless necessary
• Fexofenadine found to cross into human breast milk, not recommended for breastfeeding mothers

Precautions & Warnings

• Limited data in older people and renally or hepatically impaired patients
• Patients with cardiovascular disease should be warned about potential adverse reactions

Use in Special Populations

• Altered pharmacokinetics in individuals with renal impairment
• Adverse events similar in elderly patients

Overdose Effects

• Reported effects of overdose include dizziness, drowsiness, fatigue, and dry mouth
• Maximum tolerated dose not established, standard measures for removal of unabsorbed product

Therapeutic Class

• Non-sedating antihistamines

Storage Conditions

• Keep in a dry place away from light and heat, out of the reach of children

Chemical Structure

• Molecular Formula: C32H39NO4
• Chemical Structure Image Provided

Common Questions

• Relief of allergy symptoms such as runny nose, itching eyes/nose, sneezing, hives, and itching
• Potential side effects include vomiting, headache, and drowsiness
• Instructions for storage and disposal provided
• Potential to cause sleepiness, quick onset of action within 1 hour
• Relief of symptoms caused by outdoor and indoor allergens
• Cautions about dizziness and combining with antacids

Interaction with Other Medications

• Potential interaction with erythromycin, ketoconazole, omeprazole, and antacids

Recommended Dosage

• Several dosage options available based on age and condition, adjusted for impaired renal function

Potential Side Effects

• Range of possible side effects including dizziness, tiredness, and gastrointestinal discomfort

Use During Pregnancy and Breastfeeding

• Limited data and potential impact on pregnancy and breastfeeding

Special Populations

• Altered pharmacokinetics in renal impaired individuals and elderly patients
• Similar adverse event profile in older patients

Overdose Management

• Reported effects and standard management of overdose cases

Chemical Composition

• Molecular formula provided for the chemical structure

FAQs

• Information on uses, side effects, storage, potential sleepiness, and relief of allergy symptoms

Pharmacological Action

• Fexofenadine is considered an 'inverse agonist' of the H1 receptor
• Selective affinity for H1 receptors and lack of evidence for other activities

Administration Guidelines

• Specific dosing instructions for different age groups and impaired renal function

Potential Interactions

• Information on potential drug interactions with specific medications

Adverse Events

• Common and uncommon adverse events reported, including potential hypersensitivity reactions

Pregnancy and Breastfeeding Precautions

• Limited data on use during pregnancy and potential transfer to breast milk
• Recommendations for caution in pregnancy and breastfeeding

Special Patient Populations

• Altered pharmacokinetics in individuals with renal impairment and elderly patients
• Similar adverse event profile in older patients

Management of Overdose

• Reported effects of overdose and standard management recommendations

Structure and Composition

• Provided molecular formula and chemical structure image

FAQ

• Common questions about the medication, covering uses, side effects, storage, and potential interactions

Actions on Histamine Receptors

• Fexofenadine's interaction with H1 histamine receptor and downstream effects explained

Recommended Dosing

• Specific dosing recommendations for different age groups and renal impairment

Potential Drug Interactions

• Notable interactions with specific medications elucidated

Potential Adverse Reactions

• Range of adverse reactions reported, including potential hypersensitivity reactions

Precautions During Pregnancy and Breastfeeding

• Cautionary notes on use during pregnancy and breastfeeding
• Potential transfer to breast milk and impact on fertility

Special Considerations for Different Populations

• Pharmacokinetic alterations in renal impairment and elderly patients

Overdose Management Strategies

• Reported effects of overdose and recommendations for management

Chemical Makeup

• Provided molecular formula and image of the chemical structure

Frequently Asked Questions

• Common queries addressed regarding uses, side effects, and storage

Pharmacodynamic Features

• Details on fexofenadine's action on H1 receptors and downstream effects

Dosage Recommendations

• Clear dosing instructions based on age and renal function impairment

Interactions with Other Drugs

• Notable interactions with specific medications detailed

Potential Adverse Effects

• Reported adverse reactions, including common and uncommon effects

Safety During Pregnancy and Breastfeeding

• Limited data on use during pregnancy and impact on breastfeeding
• Potential effect on fertility based on animal studies

Considerations for Special Populations

• Altered pharmacokinetics in renal impairment and elderly patients
• Similar adverse event profile in older patients

Overdose Response

• Reported effects of overdose and general recommendations for management

Chemical Formula

• Provided molecular formula and visual representation of the chemical structure

Common Queries

• Frequently asked questions covering uses, side effects, and storage

Pharmacological Mechanism

• Details on fexofenadine's interaction with H1 receptors and downstream effects

Dosage Instructions

• Specific dosing guidance based on age and renal function impairment

Drug Interaction Potential

• Explanation of potential interactions with specific medications

Possible Adverse Reactions

• Reported adverse effects, including common and uncommon manifestations

Safety in Pregnancy and Breastfeeding

• Limited data on use during pregnancy and impact on breastfeeding
• Potential consequences for fertility based on animal studies

Special Population Considerations

• Altered pharmacokinetics in renal impairment and elderly patients
• Similar adverse event profile in older patients

Managing Overdose

• Reported effects of overdose and general strategies for managing overdose incidents

Chemical Makeup Details

• Provided molecular formula and imagery depicting the chemical structure

Frequently Asked Queries

• Common questions addressed regarding uses, side effects, and storage

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