Esotid MUPS 20 mg (MUPS Tablet)

Title

• Esotid MUPS 20 Tablet
• Esomeprazole MUPS 40 Tablet

Categories

• Medicine
• Healthcare
• Pharmaceutical

Description

• Esomeprazole MUPS tablets indicated for the treatment of Gastro-esophageal Reflux Disease (GERD)
• Feasible for Risk reduction in NSAID associated gastric ulcer
• Suitable for H. pylori eradication (Triple therapy)
• Effective for Zollinger-Ellison syndrome and idiopathic hypersecretion
• MUPS is abbreviation for Multiple-Unit Pellet System
• Ensures greater bioavailability
• Uniform emptying of micro pellets from stomach into small intestine facilitates rapid dissolution of enteric coating and drug release resulting in early Tmax and Cmax
• Combines fast acting and sustained action
• Enables uniform drug release
• Allows once daily dosing
• Better than capsules in reducing the esophageal residence time
• Minimizes fluctuation in plasma concentration of drug
• Facilitates rapid and uniform gastric emptying
• Facilitates uniform drug absorption
• Results in consistent and controlled pharmacological action
• Inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system
• Effective for short-term treatment of gastric and duodenal ulcers
• Used in prevention and treatment of NSAID associated gastric ulcers
• Swallowed whole with liquid
• Should not be chewed or crushed
• Can be dispersed in half a glass of non-carbonated water
• Metabolized in the liver by CYP2C19 and CYP3A4
• Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
• No clinically relevant interactions with drugs metabolized by these CYP enzymes
• May potentially interfere with CYP2C19, the major Esotid MUPS metabolizing enzyme
• Not approved for use in children younger than 1 year
• Contraindicated in patient with known hypersensitivity to any of the formulation
• Possible side effects include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth
• Advised caution during pregnancy and lactation
• Should be used carefully if the patient has severe liver dysfunction and severe renal impairment
• May slightly increase the risk of hip, wrist and spine fracture
• Storage at cool & dry place below 25°C, protect from light
• Chemical Structure: C17H19N3O3S
• Common side effects like headaches, diarrhea, nausea, gas, stomach pain, constipation, and dry mouth
• PPIs reduce the amount of acid produced in the stomach
• Used to treat gastroesophageal reflux disease (GERD), ulcers, and other conditions that involve too much stomach acid

Composition

• 133.333 mg (15%w/w) of Esomeprazole enteric coated pellets equivalent to 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
• 266.67 mg (15% w/w) of Esomeprazole enteric coated pellets equivalent to 40 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)

Pharmacology

• Proton pump inhibitor Esomeprazole inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system
• Effective for short-term treatment of gastric and duodenal ulcers
• Also used in prevention and treatment of NSAID associated gastric ulcers

Dosage

• Adult (≥18 years): 40 mg once daily for 4 weeks
• Children & adolescents (12-18 years): 40 mg once daily for 4 weeks
• Adult (≥18 years): 20 mg once daily
• Children & adolescents (12-18 years): 20 mg once daily
• 20 mg once daily for 4-8 weeks
• 20 mg twice daily for 7 days
• Adult (≥18 years): 20 mg twice daily for 7 days
• Children & adolescents (12-18 years): 20 mg twice daily for 7 days
• Adult (≥18 years): 40-80 mg twice daily
• Children 1-11 years: Weight <20 kg: 10 mg once daily for 8 weeks. Weight ≥20 kg: 10 mg or 20 mg once daily for 8 weeks
• Maintenance of healing of erosive esophagitis: 10 mg once daily

Administration

• Esomeprazole MUPS tablets should be swallowed whole with liquid
• Tablets should not be chewed or crushed
• Can be dispersed in half a glass of non-carbonated water
• No other liquids should be used
• Pellets must not be chewed or crushed

Interaction

• Extensively metabolized in the liver by CYP2C19 and CYP3A4
• Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
• No clinically relevant interactions with drugs metabolized by these CYP enzymes
• Inhibits gastric acid secretion
• May interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability

Contraindications

• Contraindicated in patient with known hypersensitivity to any of the formulation

Side effects

• Headache
• Diarrhoea
• Nausea
• Flatulence
• Abdominal pain
• Constipation
• Dry mouth

Pregnancy lactation

• Manufacturer advises caution during pregnancy and lactation
• Not known if Esomeprazole or its metabolites appear in human breast milk

Precautions warnings

• Should be used carefully if the patient has severe liver dysfunction and severe renal impairment
• Taking a proton pump inhibitor like Esotid MUPS may slightly increase the risk of hip, wrist and spine fracture, particularly when it is taken over a period of more than one year

Storage conditions

• Store in a cool & dry place below 25ºC
• Protect from light
• Keep out of reach of children

Chemical structure

• Molecular Formula : C17H19N3O3S
• Chemical Structure : esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

Common questions

• What is Esotid MUPS 20 mg MUPS Table?
• What is MUPS Tablet?
• What is Esotid MUPS 20 mg MUPS Table used for?
• What are the side effects of Esotid MUPS 20 mg MUPS Table?
• Can I take Esotid MUPS 20 mg MUPS Table if I am pregnant or breastfeeding?
• How long does it take for Esotid MUPS 20 mg MUPS Table to work?

Quick tips

• Esotid MUPS 20 mg MUPS Table is a well-tolerated medicine and provides relief for a long time
• Avoid eating late at night or before bedtime
• Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away
• Long-term use of Esotid MUPS 20 mg MUPS Table can cause weak bones and a deficiency of minerals such as magnesium
• Consult your doctor right away if you develop decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. These could be signs of a kidney problem

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