Parinox 6000 Anti-Xa IU/0.6 ml (SC Injection)

0.6 ml pre-filled syringe: ৳ 575.00

Medicine Details

Category Details
Generic Enoxaparin sodium
Company Incepta pharmaceuticals ltd
Also available as
Parinox 2000 anti xa injection Parinox 4000 anti xa injection Parinox 8000 anti xa injection

Title and Categories

  • Parinox Medicine
  • Anticoagulant
  • Parenteral Anticoagulant
  • Low Molecular Weight Heparin
  • Enoxaparin Sodium BP 20 mg
  • Enoxaparin Sodium BP 40 mg
  • Enoxaparin Sodium BP 60 mg
  • Enoxaparin Sodium BP 80 mg

Dimensions

Pre-filled syringes with varying volumes: 0.2 ml, 0.4 ml, 0.6 ml, 0.8 ml

Color Options

No specific color options mentioned

Functions

  • Treatment of deep vein thrombosis
  • Treatment of unstable angina and non-Q-wave myocardial infarction
  • Prevention of thrombus formation in extra corporeal circulation during hemodialysis
  • Prophylaxis of venous thromboembolic disease in surgical patients
  • Prophylaxis of venous thromboembolic disease in medical patients

Materials

Enoxaparin Sodium

Technical Specifications

  • Enoxaparin Sodium BP 20 mg equivalent to 2000 anti-Xa III
  • Enoxaparin Sodium BP 40 mg equivalent to 4000 anti-Xa III
  • Enoxaparin Sodium BP 60 mg equivalent to 6000 anti-Xa IU
  • Enoxaparin Sodium BP 80 mg equivalent to 8000 anti-Xa IU

Design Elements

Pre-filled syringes

Usability Features

  • Subcutaneous administration
  • Deep subcutaneous route
  • Intravascular route during hemodialysis

Indications

  • Treatment of Deep Vein Thrombosis:
    • With or without pulmonary embolism
  • Treatment of Unstable Angina and Non-Q-wave Myocardial Infarction:
    • Administered concurrently with aspirin
  • Prevention of Thrombus Formation in Extra Corporeal Circulation During Hemodialysis:
    • Prophylaxis of Venous Thromboembolic Disease in Surgical Patients:
      • Patients undergoing general surgery
      • Patients undergoing orthopedic surgery
    • Prophylaxis of Venous Thromboembolic Disease in Medical Patients:

      Composition

      • Each 0.2 ml pre-filled syringe contains Enoxaparin Sodium BP 20 mg
      • Each 0.4 ml pre-filled syringe contains Enoxaparin Sodium BP 40 mg
      • Each 0.6 ml pre-filled syringe contains Enoxaparin Sodium BP 60 mg
      • Each 0.8 ml pre-filled syringe contains Enoxaparin Sodium BP 80 mg

      Pharmacology

      Low molecular weight heparin with high anti-Xa activity and low anti-IIa or antithrombin activity

      Dosage

      • Treatment of Deep Vein Thrombosis:
        • Subcutaneously 100 anti-Xa IU/kg twice daily for 10 days
        • Subcutaneously 150 anti-Xa IU/kg once daily for 10 days
      • Treatment of Unstable Angina and Non-Q-wave Myocardial Infarction:
        • Subcutaneously 100 anti-Xa IU/kg twice daily for 2-8 days
      • Prevention of Thrombus Formation in Extra Corporeal Circulation During Hemodialysis:
        • Recommended dose is 100 anti-Xa IU/kg
      • Prophylaxis of Venous Thromboembolic Disease in Surgical Patients:
        • Patients undergoing general surgery with a moderate risk of thromboembolism
        • Patients undergoing orthopedic surgery with a high risk of thromboembolism
      • Prophylaxis of Venous Thromboembolic Disease in Medical Patients:
        • Subcutaneously 4000 anti-Xa IU once daily for 6-14 days

      Administration

      • Injection site preparation instructions
      • Dose selection guidelines
      • Injection guidelines
      • Post-injection precautions

      Interaction

      • Recommendations on discontinuing agents affecting hemostasis prior to Parinox therapy
      • Specific medications to be discontinued and used with caution

      Contraindications

      • Known hypersensitivity to Enoxaparin Sodium, heparin, or other low molecular weight heparins
      • Active major bleeding
      • Conditions with a high risk of uncontrolled hemorrhage including recent hemorrhagic stroke

      Side Effects

      • Haemorrhage (bleeding)
      • Thrombocytopenia
      • Elevations of serum aminotransferase
      • Pain at injection sites
      • Skin rash at injection sites
      • Cases of neuraxial hematomas with concurrent use of Parinox and spinal/epidural anesthesia or spinal puncture

      Pregnancy & Lactation

      • Pregnancy category B
      • Potential for crossing the placental barrier
      • Recommendations for nursing women

      Precautions & Warnings

      • Route of administration
      • Caution in conditions with increased potential for bleeding
      • Platelet count monitoring recommendations

      Use in Special Populations

      • Dose in Elderly Patients
      • Dose in Renal Impairment
      • Dose in Hepatic Impairment

      Overdose Effects

      Accidental overdosage and treatment with protamine sulfate

      Therapeutic Class

      Parenteral anticoagulants

      Storage Conditions

      • Cool and dry storage
      • Protection from light and moisture
      • Storage temperature not to exceed 25°C
      • Storage restrictions for refrigerator and freezer

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