Warin 5 mg (Tablet)

Unit Price: ৳ 3.00 (10 x 10: ৳ 300.00)

Strip Price: ৳ 30.00

Medicine Details

Category	Details
Generic	Warfarin sodium
Company	Incepta pharmaceuticals ltd
Also available as	Warin 2 mg tablet

Indications

Prophylaxis and/or treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement
Indicated to reduce the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after myocardial infarction
Prophylaxis and treatment of venous thrombosis and pulmonary embolism
Transient ischaemic attacks

Description

Anticoagulant that inhibits the synthesis of vitamin K dependent clotting factors (II, VII, IX, X)

Pharmacology

Acts by inhibiting the production of vitamin K by vitamin K epoxide reductase, leading to interruption of the coagulation cascade

Dosage & Administration

Usual adult induction dose of 10 mg daily for 2 days
Subsequent maintenance dose of 3 to 9 mg daily
Initial pediatric dose usually 0.1 mg.kg-1.d-1

Interaction

Has a greater potential for clinically significant drug interactions

Contraindications

Actual or potential hemorrhagic conditions
Severe hepatic or renal disease
Pregnancy
Known hypersensitivity to warfarin
Bacterial endocarditis
Use within 24 hours following surgery or labor

Side Effects

Hemorrhage
Nausea
Vomiting
Diarrhea
Hypersensitivity
Rash
Alopecia
Unexplained drop in haematocrit
Purple toes
Skin necrosis
Jaundice
Hepatic dysfunction

Pregnancy & Lactation

Contraindicated in the first trimester due to risk of teratogenicity and fatal hemorrhage to the fetus

Precautions & Warnings

Periodic determination of prothrombin time (PT)/international normalized ratio (INR) essential, monitor patients' response with additional PT/INR determination

Overdose Effects

Excessive depression of coagulation activity can be corrected by temporary withdrawal and supplementation with vitamin K or co-factor concentrates