Vomiren 0.5 mg (Tablet)
Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Palonosetron |
| Company | Renata limited |
| Also available as |
Title
- Vomiren
Categories
- Medicine
- Pharmaceutical
Description
- Palonosetron indicated for various types of nausea and vomiting, pharmacological action as a 5-HT3 receptor antagonist, dosage for adults and children, interaction with other drugs, contraindications, side effects, pregnancy and lactation category, use in special population, overdose effects, therapeutic class, and storage conditions.
Indications
- Acute and delayed nausea and vomiting
- Uncontrolled nausea and vomiting
- Chemotherapy-induced nausea and vomiting (CINV)
- Radiotherapy-induced nausea and vomiting (RINV)
- Post-operative & Post-discharge nausea and vomiting (PONV & PDNV)
Mode of Action
- Palonosetron is a 5-HT3 receptor antagonist with strong binding affinity for this receptor and little or no affinity for other receptors. It works by blocking the actions of Serotonin at 5-HT3 receptors. It is likely that Palonosetron works in the small intestine but it may also work in the brain. Pharmacokinetics include linear dose-proportional behavior, volume of distribution, metabolism percentages, excretion, total body clearance, renal clearance, and longer half-life.
Dosage & Administration
- Usual dosage for adults, chemotherapy-induced nausea and vomiting dosage, radiotherapy-induced nausea and vomiting dosage, post-operative nausea and vomiting dosage, and children dosage.
Interaction
- Safely administered with corticosteroids, analgesics, antiemetics/antinauseants, antispasmodics, and anticholinergic agents. No inhibition of the antitumor activity of certain drugs. No significant pharmacokinetic interactions with metoclopramide. Not an inhibitor or inducer of specific enzymes.
Contraindications
- Contraindicated in patients known to have hypersensitivity to the drug or any of its components.
Side Effects
- The most common adverse reactions are headaches and constipation.
Pregnancy & Lactation
- Pregnancy category 'B'. It is not known whether Palonosetron is excreted in breast milk.
Use in Special Populations
- No dosage adjustment is recommended in elderly patients >65 years of age. Use in children (1 month to 10 years) with specific dosage. No dosage adjustment is recommended in patients with renal and hepatic dysfunction.
Overdose Effects
- There is no known antidote to Vomiren. Overdose should be managed with supportive care.
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store in a cool & dry place, protected from light.