Ezyout 5 mg/5 ml (Oral Solution)

Indications

• Constipation of any etiology
• Relief from prolonged & recurrent constipation
• Bowel clearance before surgery, childbirth or radiological investigations.

Pharmacology

Sodium Picosulfate is a triarylmethane group derivative stimulant laxative. After oral administration it is activated by the colonic bacteria and acts locally in the colon. The active form then stimulates the nerve endings of the intestinal wall and results in colonic peristalsis with promotion of accumulation of water and electrolytes in the colonic lumen.

Dosage & Administration

• 10 mg tablet dose:
  • Adults and children over 10 years of age: 5-10 mg per day.
  • Children aged 4-10 years: 2.5-5 mg per day.
• Oral Solution (5 mg/5 ml) dose:
  • Adults and children over 10 years of age: 5-10 ml or one to two teaspoonful per day.
  • Children aged 4-10 years: 2.5-5 ml or half to one teaspoonful per day.
  • Children from One month to 4 years of age: 0.25 ml/kg body weight per day.
• Concentrated Oral Solution (7.5 mg/ml) dose:
  • Adults and children over 10 years of age: 0.67-1.33 ml per day.
  • Children aged 4-10 years: 0.33-0.67 ml per day.

Interaction

The concomitant use of diuretics or adreno-corticosteroids may increase the risk of electrolyte imbalance if excessive doses are taken. Concurrent administration of antibiotics may reduce the laxative action of Ezyout.

Contraindications

Ileus or intestinal obstruction, severe painful and/or feverish acute abdominal conditions (e.g. appendicitis) potentially associated with nausea and vomiting, acute inflammatory bowel diseases, severe dehydration, known hypersensitivity to Sodium Picosulfate or any other component of the product.

Side Effects

• Hypersensitivity
• dizziness
• syncope
• gastrointestinal disorders
• diarrhea
• abdominal pain and cramps
• nausea
• vomiting

Pregnancy & Lactation

Ezyout 5 mg/5 ml Solution is not recommended during the first trimester. Clinical data show that neither the active moiety of sodium Picosulfate nor its glucuronides are excreted into the milk of healthy lactating females.

Precautions & Warnings

Prolonged excessive use may lead to fluid and electrolyte imbalance and hypokalemia. Harmful for those suffering from alcoholism. To be taken into account in pregnant or breast-feeding women, children and high-risk groups such as patients with liver disease or epilepsy.

Overdose Effects

Laxatives when taken in chronic overdosage may cause chronic diarrhea, abdominal pain, hypokalemia, secondary hyperaldosteronism, and renal calculi. Renal tubular damage, metabolic alkalosis, and muscle weakness secondary to hypokalemia have also been described in association with chronic laxative abuse.

Therapeutic Class

Stimulant Laxative

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Chemical Structure

• Molecular Formula: C18H15NNa2O9S2
• Chemical Structure Image: https://medex.com.bd/storage/res/g-res-1480-sodium-picosulfate-chemical-structure-VXribBHk7yHHQxt7umhH.svg

Common Questions about Ezyout 5 mg/5 ml Oral Solution

• What is Ezyout 5 mg/5 ml Solution?: Ezyout 5 mg/5 ml Solution belongs to the class of laxatives.
• What are the uses of the Ezyout 5 mg/5 ml Solution?: Ezyout 5 mg/5 ml Solution is used in the treatment of constipation.
• How long do I need to use Ezyout 5 mg/5 ml Solution before I see improvement in my condition?: Ezyout 5 mg/5 ml Solution is to be taken till the time you see an improvement in your health conditions.
• At what frequency do I need to use Ezyout 5 mg/5 ml Solution?: Ezyout 5 mg/5 ml Solution should be taken in the dosage as prescribed by the doctor.
• Should I use Ezyout 5 mg/5 ml Solution empty stomach, before food or after food?: Ezyout 5 mg/5 ml Solution should be taken at bed-time as it requires 6-8 hours to show effect.
• What are the instructions for the storage and disposal of Ezyout 5 mg/5 ml Solution?: Ezyout 5 mg/5 ml Solution should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.
• Is Ezyout 5 mg/5 ml Solution safe for pregnant women?: Ezyout 5 mg/5 ml Solution is not prescribed to pregnant women unless necessary. Consult your doctor beforehand.
• Is Ezyout 5 mg/5 ml Solution safe for breastfeeding women?: Breastfeeding women are not suggested to take Ezyout 5 mg/5 ml Solution unless necessary. Consult your doctor beforehand.
• Is Ezyout 5 mg/5 ml Solution a habit forming drug?: No case of addiction has been reported yet.
• What if I miss a dose of Ezyout 5 mg/5 ml Solution?: Take Ezyout 5 mg/5 ml Solution as soon as you remember. However, stick to your routine if it's the time for the next dose. Do not double the dose.
• Quick Tips:
  • Together with Ezyout 5 mg/5 ml Solution, taking a fiber-rich diet containing whole grain bread and cereals, bran, fruits and green leafy vegetables, is essential to maintain healthy bowel function.
  • Avoid taking Ezyout 5 mg/5 ml Solution for more than 1 week, unless prescribed by the doctor, as it leads to dependency on the laxative action to produce a bowel movement.
  • Take Ezyout 5 mg/5 ml Solution after 2 hours from other medicines, as it may interfere with the absorption of other medicines.
  • Ezyout 5 mg/5 ml Solution should be preferably taken at bedtime because it requires 6 to 8 hours to show impact.

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