Anlet 75 mg (Tablet)

Indications

• Reduction of myocardial infarction (MI) rate
• Reduction of stroke rate
• Treatment for non-ST-segment elevation ACS
• Treatment for unstable angina (UA)
• Treatment for non-ST-elevation myocardial infarction (NSTEMI)
• Treatment for acute ST-elevation myocardial infarction (STEMI)
• Prevention of recent MI
• Prevention of recent stroke
• Prevention of peripheral arterial disease
• Reduction of bleeding risk
• Antiplatelet effect

Pharmacology

• Prodrug
• Inhibition of platelet activation
• Irreversible binding to P2Y12 receptors
• Dose-dependent inhibition of platelet aggregation
• Onset of action within 2 hours
• Steady state inhibition between Day 3 and Day 7

Dosage & Administration

• Loading dose of 300 mg (4 tablets)
• Maintenance dose of 75 mg once daily
• Oral administration
• Fast antiplatelet effect when initiated with a loading dose

Interaction

• Increased risk of bleeding with NSAIDs, warfarin, SSRIs, SNRIs
• Avoid concomitant use with CYP2C19 inhibitors like omeprazole or esomeprazole
• Increased plasma concentrations of Repaglinide when used concomitantly

Contraindications

• Hypersensitivity to the drug substance or any component
• Active pathological bleeding such as peptic ulcer or intracranial hemorrhage

Side Effects

• Common: Bleeding, Diarrhoea, gastrointestinal discomfort, haemorrhage, Skin reactions
• Rare: Acquired haemophilia, anaemia, angioedema, arthralgia, arthritis, bone marrow disorders

Pregnancy & Lactation

• Use during pregnancy only if clearly needed
• Unknown excretion in human breast milk
• Decision making for breastfeeding mothers

Precautions & Warnings

• Metabolism impairment in CYP2C19 poor metabolizer
• Risk of bleeding due to lifelong platelet aggregation inhibition
• Increased risk of cardiovascular events after discontinuation
• Reported cases of Thrombotic Thrombocytopenic Purpura (TTP)
• Reported cases of hypersensitivity reactions

Use in Special Populations

• Safety and effectiveness not established in pediatric populations
• No dosage adjustment necessary in elderly patients

Overdose Effects

• May lead to bleeding complications
• Potential restoration of clotting ability with platelet transfusion

Therapeutic Class

• Anti-platelet drugs

Storage Conditions

• Keep below 30°C temperature
• Store in a dry place
• Protected from light
• Avoid freezing
• Keep out of reach of children

Related Brands

• Anclog 75 mg (Tablet) - square-pharmaceuticals-plc