Prevastin 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Omeprazole
Company Royal pharmaceutical ltd

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Returns gradually over 3 to 5 days after discontinuation

Dosage

  • Oral dosage for benign gastric and duodenal ulcer
  • Oral dosage for NSAID-associated duodenal or gastric ulcer
  • Oral dosage for gastro-esophageal reflux disease
  • Dosage for long-term management of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Omeprazole dosage in Helicobacter pylori eradication regimen
  • Pediatric use in severe ulcerating reflux esophagitis
  • IV Injection dosage for prophylaxis of acid aspiration
  • IV Injection dosage for duodenal ulcer, gastric ulcer or reflux oesophagitis
  • IV Injection dosage for Zollinger-Ellison syndrome
  • Administration directions for IV Injection
  • Administration directions for IV Infusion

Interaction

  • Decreased intragastric acidity affecting the absorption of ketoconazole
  • Metabolism through cytochrome P450 affecting diazepam, phenytoin, and warfarin
  • Monitoring and potential dose reduction for patients receiving warfarin or phenytoin
  • Plasma concentrations of Prevastin and clarithromycin during administration
  • Absence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, or antacids

Contraindications

  • Known hypersensitivity to omeprazole
  • Exclusion of malignancy when gastric ulcer is suspected

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
  • Diarrhoea and headache
  • Gastrointestinal reactions including constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Paraesthesia, dizziness, light headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Other reported symptoms

Pregnancy & Lactation

  • No adverse effects on pregnancy or health of the fetus/newborn child
  • Use during pregnancy
  • Discontinuation of breastfeeding if essential use

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Prevastin
  • Increased risk for osteoporosis-related fractures
  • Atrophic gastritis in patients treated long-term
  • Concomitant use with methotrexate

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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