Domerin 10 mg (Tablet)

Unit Price: ৳ 2.50 (10 x 10: ৳ 250.00)
Strip Price: ৳ 25.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Royal pharmaceutical ltd

Title and Categories

  • Domperidone 10mg Tablet
  • Medicine
  • Pharmaceuticals
  • Gastrointestinal
  • Prokinetic
  • Dopamine Antagonist

Dosage Form

Tablet

Packaging

Blister pack

Color

White

Shape

Round

Dimensions

6mm diameter

Primary Function

Relieves nausea and vomiting

Secondary Function

Improves gastric motility

Indications

  • Dyspeptic symptom complex
  • Delayed gastric emptying
  • Gastroesophageal reflux
  • Esophagitis
  • Acute nausea and vomiting
  • Parkinson's disease
  • Radiological studies

Pharmacology

  • Primary Action: Dopamine receptor antagonist
  • Site of Action:
    • Chemoreceptor Trigger Zone (CTZ)
    • Stomach
  • Gastrointestinal Effects:
    • Facilitates gastric emptying
    • Enhances antral and duodenal peristalsis
    • Regulates pylorus contraction
  • Esophageal Effects:
    • Increases esophageal peristalsis
    • Regulates lower esophageal sphincter pressure
  • Brain Penetration: Weak, minimal central nervous system effects

Dosage and Administration

  • Usual Adult Dose: 10-20 mg every 6-8 hours daily
  • Maximum Adult Dose: 80 mg daily
  • Usual Pediatric Dose: 0.2-0.4 mg/kg body weight every 6-8 hours daily
  • Dosage Forms:
    • Tablet
    • Suspension
    • Paediatric Drops
  • Route of Administration:
    • Oral
    • Rectal
  • Pre-Meal Administration: 15-30 minutes
  • Maximum Treatment Period: 12 weeks

Interaction

  • Anticholinergic drugs antagonism
  • Lowered oral bioavailability with antacids and antisecretory drugs
  • Metabolic pathway through CYP3A4
  • Potential CYP3A4 inhibitors
  • Potential influence on orally administered drugs

Contraindications

  • Hypersensitivity to domperidone
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Potential increase in plasma prolactin level
  • Rare allergic reactions

Pregnancy and Lactation

  • Animal Studies: No teratogenic effects
  • Human Studies: No evidence of increased malformation risk
  • Excretion in Breast Milk: Present
  • Recommendation: Caution advised; balance benefits and risks

Precautions and Warnings

  • Increased risk of extrapyramidal reactions in children
  • Need for caution in hepatic impairment

Special Populations

  • Use in infants
  • Use in liver disorders
  • Use in kidney disorders

Overdose Effects

Drowsiness, disorientation, extrapyramidal reactions

Overdose Management

Activated charcoal administration, close observation

Therapeutic Class

Motility stimulants, Dopamine antagonist

Storage Conditions

Below 30°C, protected from light and moisture

Chemical Structure

  • Molecular Formula: C22H24ClN5O2
  • Structural Image: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg

Common Questions

  • Use for nausea and vomiting
  • Recommendation for pre-meal use
  • Caution with alcohol consumption
  • Possible side effects and symptoms to report
  • Limit use to 7 days without consultation

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