Leokast 10 mg (Tablet)
Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Montelukast sodium |
| Company | Royal pharmaceutical ltd |
Title
- Leokast 10 mg Tablet
Categories
- Medicine
- Pharmaceutical
Description
- Selective and orally active leukotriene receptor antagonist
- Prophylaxis and chronic treatment of asthma
- Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
- Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis
- Cysteinyl leukotriene receptor antagonist
- Inhibition of cysteinyl leukotriene receptor (CysLT1)
- Leukotriene receptor antagonist
- Oral medication for asthma and allergic rhinitis treatment
- Orally administered montelukast formulation
- Dosage for adults and adolescents 15 years of age and older: Montelukast 10 mg tablet once daily
- Dosage for pediatric patients 6 to 14 years of age: Montelukast 5 mg tablet once daily
- Dosage for pediatric patients 2 years to 5 years of age: Montelukast 4 mg tablet once daily
- Dosage for pediatric patients 6 months to 5 years of age: Montelukast 4 mg oral granules once daily
- Storage in cool & dry place below 30°C, protect from light & moisture
- Crosses the placenta following oral dosing in rats and rabbits
- Pregnancy category: Use during pregnancy only if clearly needed
- Caution should be exercised when given to a nursing mother
- Not indicated for use in the reversal of bronchospasm in acute asthma attacks
- Therapeutic class: Leukotriene receptor antagonists
Indications
- Prophylaxis and chronic treatment of asthma
- Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
- Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis
Pharmacology
- Selective and orally active leukotriene receptor antagonist
- Inhibition of cysteinyl leukotriene receptor (CysLT1)
- Correlation with the pathophysiology of asthma & allergic rhinitis
Dosage and administration
- Dosage for adults and adolescents 15 years of age and older: Montelukast 10 mg tablet once daily
- Dosage for pediatric patients 6 to 14 years of age: Montelukast 5 mg tablet once daily
- Dosage for pediatric patients 2 years to 5 years of age: Montelukast 4 mg tablet once daily
- Dosage for pediatric patients 6 months to 5 years of age: Montelukast 4 mg oral granules once daily
- No dosage adjustment required in patients with mild-to-moderate hepatic insufficiency
- No dosage adjustment recommended in patients with renal insufficiency
- Similar pharmacokinetic profile in elderly and younger adults
- Plasma half-life slightly longer in the elderly
- No dosage adjustment required for the elderly
Interaction
- No apparent increase in adverse reactions when administered with other therapies for asthma
- No clinically important effects on the pharmacokinetics of specific drugs observed
- Wide range of concomitantly used drugs in clinical studies without evidence of clinical adverse interactions
- Phenobarbital decreased the AUC of Leokast approximately 40% following a single 10mg dose
Contraindications
- Hypersensitivity to any component of this product
Side effects
- Common: Diarrhoea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory tract infection
- Uncommon: Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, haemorrhage, irritability, malaise, muscle complaints, oedema, seizure, abnormal sensation, sleep disorders
- Rare: Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor
Pregnancy and lactation
- Crosses the placenta following oral dosing in rats and rabbits
- Use during pregnancy only if clearly needed
- Caution should be exercised when given to a nursing mother
Precautions and warnings
- Not indicated for use in the reversal of bronchospasm in acute asthma attacks
- Appropriate rescue medication advice for patients
- Continued therapy during acute exacerbations of asthma
- Not to be abruptly substituted for inhaled or oral corticosteroids
- Should not be used as monotherapy for the treatment and management of exercise induced bronchospasm
- Avoidance of aspirin or non-steroidal anti-inflammatory agents for patients with known aspirin sensitivity
Overdose effects
- No adverse experiences in the majority of overdosage reports
- Adverse experiences consistent with the safety profile of Leokast observed
Drug classes
- Leukotriene receptor antagonists
Storage conditions
- Store in cool & dry place below 30°C, protect from light & moisture
Compound summary
- Molecular Formula: C35H36ClNO3S
- Chemical Structure available
Commonly asked questions
- Leokast 10 mg Tablet is commonly used to treat asthma or allergic rhinitis
- Effect can be observed after 1-3 hours of administration
- Effect lasts for an average duration of 24 hours
- May be taken with or without food as prescribed by the doctor
- Use should be avoided in pregnant women unless clearly needed
- Caution in dose changes or stopping of asthma medication without doctor's advice