Mepal 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 6.00 (6 x 10: ৳ 360.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Esomeprazole
Company Royal pharmaceutical ltd

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Treatment of acid-related Dyspepsia
  • Treatment of Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • First single optical isomer of proton pump inhibitor
  • Enteric-coated pellet formulation
  • Metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Excretion in urine and feces
  • Combination therapy with antimicrobials

Dosage

  • 20 mg or 40 mg Once Daily for healing of erosive esophagitis
  • 20 mg Once Daily for maintenance of healing of erosive esophagitis
  • 20 mg Once Daily for symptomatic GERD
  • Triple Therapy for Helicobacter Pylori eradication
  • 20-80 mg Once Daily for Zollinger-Ellison Syndrome
  • 20-40 mg Once Daily for Acid-related Dyspepsia
  • 20 mg Once Daily for Duodenal ulcer
  • 20-40 mg Once Daily for Gastric ulcer
  • IV Injection or IV infusion dosage for various conditions

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Instructions for Oral Suspension administration
  • Instructions for IV Injection administration

Interactions

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically relevant interactions with certain CYP enzymes
  • Potential interference with CYP2C19
  • No significant interactions with specific drugs

Contraindications

  • Known hypersensitivity to the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Excretion in milk not studied
  • Breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Instructions for patients
  • Use of antacids while taking Mepal

Use in Special Populations

  • Safety and effectiveness not established in paediatric patients
  • No overall differences in safety and efficacy in elderly patients
  • No dosage adjustment for mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in renal impairment

Overdose Effects

  • Acute toxicity signs in animal studies
  • No specific antidote known
  • Symptomatic and supportive treatment recommended

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image URL

Commonly Asked Questions

  • Definition and usage of Mepal 20 mg Tablet
  • Common side effects of Mepal 20 mg Tablet
  • Considerations for pregnancy and breastfeeding
  • Onset of action for Mepal 20 mg Tablet
  • Quick tips for using Mepal 20 mg Tablet

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