Xorel 10 mg (Tablet (Enteric Coated))

Unit Price: ৳ 3.00 (10 x 10: ৳ 300.00)
Strip Price: ৳ 30.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Ibn sina pharmaceuticals ltd
Also available as
Xorel 20 mg tablet Xorel 20 mg capsule Xorel 10 mg capsule Xorel mups 20 mg tablet

Therapeutic Class

  • Proton Pump Inhibitor

Indications

  • Treatment of active duodenal ulcer
  • Treatment of active benign gastric ulcer
  • Symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Gastro-esophageal reflux disease long-term management (GERD maintenance)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Treatment of Zollinger-Ellison Syndrome
  • Eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

  • Suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase

Dosage

  • 20mg oral dose for active duodenal ulcer and active benign gastric ulcer
  • 20mg oral dose for erosive or ulcerative GERD
  • 20mg or 10mg maintenance dose for GERD maintenance
  • 10mg oral dose for symptomatic treatment of moderate to very severe GERD
  • 5mg or 10mg oral dose for treatment of GERD in pediatric patients
  • 60mg starting dose for Zollinger-Ellison Syndrome

Administration

  • Rabeprazole tablets to be taken in the morning, before eating
  • Tablets should not be chewed or crushed, but swallowed whole

Interaction

  • Potential interaction with compounds whose absorption is pH dependent
  • Potential decrease in antifungal plasma levels when co-administered with ketoconazole or itraconazole

Contraindications

  • Hypersensitivity to the active substance or to any of the excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side Effects

  • Well-tolerated but may cause headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, increased or decreased appetite, muscle pain, drowsiness, dizziness

Pregnancy & Lactation

  • US FDA pregnancy category 'C'
  • No adequate and well-controlled studies in pregnant women
  • Likely excretion in human milk; decision should be made whether to discontinue nursing or the drug

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric or esophageal malignancy
  • Patients on long-term treatment should be kept under regular surveillance
  • May increase risk of hip, wrist, and spine fracture, especially in the elderly
  • Risk of cross-hypersensitivity reactions with other proton pump inhibitor or substituted benzimidazoles
  • May cause blood dyscrasias, hepatic enzyme abnormalities, and hypomagnesaemia

Use in Special Populations

  • No dosage adjustment necessary for patients with renal or hepatic impairment
  • Not recommended for use in children due to a lack of data on safety and efficacy

Overdose Effects

  • Maximum established exposure has not exceeded 60mg twice daily or 160mg once daily
  • Effects are generally minimal and reversible without further medical intervention
  • No specific antidote known

Storage Conditions

  • Keep below 30°C temperature, away from light & moisture
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C18H21N3O3S

Known Interactions

  • Ketoconazole
  • Itraconazole
  • Liquid antacids
  • Atazanavir

Commonly Asked Questions

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