APT 75 mg (Tablet)
Unit Price: ৳ 10.03 (2 x 10: ৳ 200.60)
Strip Price: ৳ 100.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Clopidogrel bisulphate |
| Company | Sharif pharmaceuticals ltd |
Indications
- Reduce rate of myocardial infarction (MI)
- Reduce rate of stroke
- Non-ST-segment elevation ACS
- Unstable angina (UA)
- NSTEMI
- Acute ST-elevation myocardial infarction (STEMI)
- Recent MI
- Recent Stroke
- Peripheral Arterial Disease
Pharmacology
- Prodrug
- Inhibits platelet activation
- Irreversible binding to P2Y12 ADP receptors
- Dose-dependent inhibition of platelet aggregation
Dosage & Administration
- 300 mg oral loading dose
- 75 mg once daily
- Oral administration
- With or without food
Interaction
- Increased bleeding risk with NSAIDs, warfarin, SSRIs, SNRIs
- Avoid concomitant use of omeprazole or esomeprazole
- Increased plasma concentrations of Repaglinide with concomitant use of APT
Contraindications
- Hypersensitivity to the drug substance
- Active pathological bleeding e.g. peptic ulcer, intracranial hemorrhage
Side Effects
- Bleeding
- Diarrhoea
- Gastrointestinal discomfort
- Haemorrhage
- Skin reactions
- Acquired haemophilia
- Anaemia
- Angioedema
- Arthralgia
- Arthritis
- Bone marrow disorders
Pregnancy & Lactation
- Use during pregnancy only if clearly needed
- Unknown excretion in human breast milk
- Consideration of drug importance vs. nursing
Precautions & Warnings
- Impaired metabolism by genetic variations in CYP2C19
- Increased bleeding risk due to inhibition of platelet aggregation
- Increased risk of cardiovascular events upon discontinuation
- Reported cases of Thrombotic Thrombocytopenic Purpura (TTP) requiring urgent treatment
- Hypersensitivity reactions reported
Use in Special Populations
- Safety and effectiveness in pediatric populations not established
- No dosage adjustment necessary in elderly patients
Overdose Effects
- May lead to bleeding complications
- Platelet transfusion may restore clotting ability
Therapeutic Class
- Anti-platelet drugs
Storage Conditions
- Keep below 30°C temperature
- Dry place
- Protected from light
- Do not freeze
- Keep out of the reach of children