Livadox 10 mg (Tablet)
Unit Price: ৳ 55.00 (3 x 10: ৳ 1,650.00)
Strip Price: ৳ 550.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Obeticholic acid |
| Company | Jenphar bangladesh ltd |
| Also available as |
Indications
- treatment for primary biliary cholangitis (PBC)
- combination therapy with ursodeoxycholic acid (UDCA)
- monotherapy for patients unable to tolerate UDCA
Pharmacology
- agonist for Farnesoid X Receptor (FXR)
- regulator of bile acid, inflammatory, and metabolic pathways
- decreases intracellular hepatocyte concentrations of bile acids
Mechanism of Action
- suppresses de novo synthesis of bile acids from cholesterol
- increases transport of bile acids out of hepatocytes
- limits the overall size of circulating bile acid pool
- promotes choleresis
Pharmacodynamics
- associated with a 173% increase in concentrations of FGF-19
- reduces concentrations of cholic acid and chenodeoxycholic acid
Dosage & Administration
- initial dosage of 5 mg once daily for 3 months
- maximum dosage of 10 mg once daily
- monitoring for biochemical response and tolerability
- management of intolerable pruritus
Interactions
- interaction with bile acid binding resins
- interaction with warfarin
- potential interaction with CYP1A2 substrates
- interaction with inhibitors of Bile Salt Efflux Pump
Contraindications
- decompensated cirrhosis
- compensated cirrhosis with evidence of portal hypertension
- complete biliary obstruction
Side Effects
- pruritus
- fatigue
- stomach pain
- discomfort
- rash
- arthralgia
- dizziness
- constipation
- abnormal thyroid function
- eczema
Pregnancy & Lactation
- limited available human data on use during pregnancy
- no information on presence in human milk
Precautions & Warnings
- hepatic decompensation and failure in PBC patients with cirrhosis
- severe pruritus
- reduction in HDL-C levels
- monitoring of serum lipid levels during treatment
Use in Special Populations
- pediatric use not established
- geriatric use
- hepatic impairment
Overdose Effects
- dose-dependent increase in hepatic adverse reactions
- supportive care in case of overdose
Therapeutic Class
- Farnesoid X Receptor Agonists
Storage Conditions
- store below 30°C in a dry place
- protect from light
- keep out of children’s reach