Caloren 1 mcg/ml (IV Injection)

Indications

• Post-menopausal osteoporosis
• Renal osteodystrophy
• Postsurgical hypoparathyroidism
• Idiopathic hypoparathyroidism
• Pseudohypoparathyroidism
• Secondary hyperparathyroidism in patients with moderate to severe chronic renal failure (pre-dialysis)
• Vitamin D dependent rickets

Pharmacology

Calcitriol promotes intestinal absorption of calcium and regulates bone mineralization

Dosage & Administration

• 0.25 mcg twice daily for post-menopausal osteoporosis
• 0.25 mcg every other day for renal osteodystrophy (dialysis patients)
• 0.25 mcg/day for hypoparathyroidism and rickets
• 1-2 mcg administered three times weekly for secondary hyperparathyroidism
• 0.02 mcg/kg for initial intravenous dose of Calcitriol injection

Interaction

Concomitant treatment with thiazide diuretics increases the risk of hypercalcemia

Contraindications

Hypersensitivity to any of its ingredients, and all diseases associated with hypercalcemia

Side Effects

• Weakness
• Headache
• Nausea
• Vomiting
• Dry mouth
• Constipation
• Muscle pain
• Bone pain
• Metallic taste
• Polyuria
• Polydipsia
• Anorexia
• Weight loss
• Nocturia
• Pancreatitis
• Photophobia
• Rhinorrhea
• Pruritus
• Hyperthermia
• Hypertension

Pregnancy & Lactation

May be used during pregnancy only if benefits outweigh potential risk to the fetus; serum calcium levels of mother and infant should be monitored during breastfeeding

Precautions & Warnings

• Excessive dosage induces hypercalcemia and hypercalciuria
• Given cautiously to patients on digitalis
• Discontinuation may result in rebound effect
• Vitamin D and its derivatives should be withheld during treatment
• A non-aluminum phosphate-binding compound should be used to control serum phosphorus levels in patients undergoing dialysis
• Chronic hypercalcemia can lead to generalized vascular calcification

Use in Special Populations

• Recommended initial dosage of 0.25 mcg/day in adults and pediatric patients 3 years of age or older
• Dosage may be increased if necessary to 0.5 mcg/day
• Recommended initial dosage of Caloren is 10 to 15 ng/kg/day for pediatric patients less than 3 years of age

Overdose Effects

Can cause hypercalcemia, hypercalciuria, and hyperphosphatemia

Therapeutic Class

Vitamin in bone formation, Vitamin-D preparations

Storage Conditions

Keep in a dry place away from light and heat, and out of the reach of children

Related Brands

• G-Calcitriol 1 mcg/ml (IV Injection) - gonoshasthaya-pharma-ltd