Cefdox 20 mg/ml (Pediatric Drops)
15 ml bottle: ৳ 60.41
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefpodoxime proxetil |
| Company | Aci limited |
| Also available as |
Indications
- Treatment of acute otitis media
- Treatment of pharyngitis/tonsillitis
- Treatment of acute maxillary sinusitis
- Treatment of community acquired pneumonia
- Treatment of acute bacterial exacerbation of chronic bronchitis
- Treatment of skin and skin structure infections
- Treatment of uncomplicated urinary tract infections
- Treatment of uncomplicated gonorrhea
- Treatment of rectal gonococcal infections in women
Pharmacology
- Oral 3rd generation cephalosporin
- Good stability to beta lactamases
- Activity against Gram negative and Gram positive bacteria
- Prodrug with active metabolite Cefpodoxime
- Approximately 29 to 33% excreted unchanged in urine in 12 hours
- High stability in presence of beta-lactamase enzyme
Dosage & Administration
- Adults and Adolescents:
- Pharyngitis/tonsillitis: 100 mg 12 hourly, 5 to 10 days
- Acute maxillary sinusitis: 200 mg 12 hourly, 10 days
- Community-acquired pneumonia: 200 mg 12 hourly, 14 days
- Acute bacterial exacerbations of chronic bronchitis: 200 mg 12 hourly, 10 days
- Skin and skin structure: 400 mg 12 hourly, 7 to 14 days
- Uncomplicated urinary tract infection: 100 mg 12 hourly, 7 days
- Uncomplicated gonorrhea: single dose of 200 mg
- Rectal gonococcal infections in women: single dose of 200 mg
- Infants and Pediatric Patients (2 months to 12 years):
- Acute otitis media: 5 mg/kg body weight 12 hourly, 5 days
- Pharyngitis /tonsillitis: 5 mg/kg body weight 12 hourly, 5 to 10 days
- Acute maxillary sinusitis: 5 mg/kg body weight 12 hourly, 10 days
- Patients with renal dysfunction: Dosing intervals increased to 24 hourly for severe renal impairment (creatinine clearance <30ml/min)
- Patients with liver cirrhosis: No dose adjustment necessary
Interaction
- Concomitant administration with high doses of antacids or H 2 blockers
- Renal excretion inhibited by probenecid resulting in approximately 31% increase in AUC
- Close monitoring of renal function advised when administered with compounds of known nephrotoxic potential
Contraindications
Known allergy to Cefpodoxime or to the cephalosporin group of antibiotics
Side Effects
- Diarrhea
- Nausea
- Skin & vaginal fungal infection
- Abdominal pain
- Headache
- Chest pain
- Myalgia
- Dyspepsia
- Dizziness
- Vertigo
- Cough
- Higher incidence of fungal skin rash in children
Pregnancy & Lactation
Not teratogenic or embryocidal in animal trials. Use during pregnancy only if clearly needed. Excreted in human milk
Precautions & Warnings
- Total daily dose should be reduced in patients with transient or persistent reduction in urinary output due to renal insufficiency
- Administer with caution to patients receiving concurrent treatment with potent diuretics
- Prolonged use may result in overgrowth of non-susceptible organisms
- Repeated evaluation of the patient’s condition is essential
Therapeutic Class
Third generation Cephalosporins
Reconstitution
Add 30 ml of cooled boil water to the dry mixture in the bottle. Shake well before each use. Store reconstituted suspension in a cool, dry place
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children