Benquil 15 mg (Tablet)

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Midazolam
Company Biopharma limited
Also available as
Benquil 75 mg tablet

Title and Categories

  • Benquil
  • Medicine
  • Benzodiazepine Hypnotic
  • Benzodiazepine Sedative

Indications

  • Short-term treatment of insomnia
  • Sedation in premedication before surgical or diagnostic procedures

Description

  • Sleep-inducing agent
  • Rapid onset and short duration of action
  • Anxiolytic effect
  • Anticonvulsant effect
  • Muscle-relaxant effect

Mode of Action

  • Increases activity of GABA
  • Produces sedating effect
  • Relaxes skeletal muscles
  • Induces sleep, anesthesia, and amnesia
  • Binds to the benzodiazepine site on GABA-A receptors
  • Potentiates the effects of GABA
  • Identified receptors in the central nervous system
  • Identified receptors in the heart and skeletal muscle

Dosage and Administration

  • Oral dosage for adults: 7.5-15 mg daily
  • Oral dosage for elderly and debilitated patients: 7.5 mg
  • Oral dosage for premedication: 15 mg 30-60 minutes before the procedure
  • Intravenous administration for endoscopic or cardiovascular procedures: Initial dose is approximately 2.5 mg in healthy adults, reduced initial dose for severe illness and elderly patients
  • Intravenous administration for induction of anesthesia: Dose is 10-15 mg
  • Intramuscular administration for adults: 0.07-0.1 mg/kg body weight, usual dose is about 5 mg
  • Intramuscular administration for children: 0.15-0.20 mg/kg
  • Intramuscular administration for elderly and debilitated patients: 0.025-0.05 mg/kg
  • Rectal administration in children for preoperative sedation: 0.35-0.45 mg/kg 20-30 min before induction of general anesthesia

Interaction

  • Enhances the central sedative effect of various drugs like neuroleptics, antidepressants, analgesics, anesthetics, antipsychotics, antiepileptic drugs, and sedative antihistamines

Contraindications

  • Severe respiratory insufficiency
  • Severe hepatic insufficiency
  • Myasthenia gravis
  • Sleep apnea syndrome
  • Known hypersensitivity to benzodiazepines or any component of the product

Side Effects

  • Drowsiness
  • Confusion
  • Fatigue
  • Headache
  • Muscle weakness
  • Fluctuations in vital signs including respiratory depression, apnea, variations in blood pressure, and pulse rate

Pregnancy and Lactation

  • Avoid during pregnancy unless no safer alternative
  • Avoid during breastfeeding as it passes into breast milk

Precautions and Warnings

  • Administer Benquil IV very slowly

Overdose Effects

  • Coma
  • Areflexia
  • Cardiorespiratory depression
  • Apnea
  • Controlled with benzodiazepine antagonist flumazenil

Therapeutic Class

  • Benzodiazepine hypnotics
  • Benzodiazepine sedatives

Storage Conditions

  • Protect from light and moisture
  • Store in cool and dry place
  • Keep out of the reach of children

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