Defcort 6 mg (Tablet)
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Deflazacort |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Anaphylaxis
- Asthma
- Rheumatoid arthritis
- Juvenile chronic arthritis
- Systemic lupus erythematosus
- Dermatomyositis
- Mixed connective tissue disease
- Polyartritis nodosa
- Sarcoidosis
- Pemphigus
- Bullous pemphigoid
- Pyoderma gangrenosum
- Minimal change nephrotic syndrome
- Acute interstitial nephritis
- Rheumatic carditis
- Ulcerative colitis
- Crohn's disease
- Uveitis
- Optic neuritis
- Autoimmune haemolytic anaemia
- Idiopathic thrombocytopenic purpura
- Acute and lymphatic leukaemia
- Malignant lymphoma
- Multiple myeloma
- Immune suppression in transplantation
Pharmacology
- Anti-inflammatory action
- Inhibition of Phospholipase A2 enzyme
- Prostaglandin synthesis inhibition
- Immunosuppressive action
- Decreased release of certain chemicals
Dosage & Administration
- Adult dosage range of 3-120 mg/day
- Maintenance dose for most conditions within 3-18 mg/day range
- Titration to lowest effective dose
- Children's dosage range of 0.25-1.5 mg/kg/day
- Alternate day administration may be appropriate
- Withdrawal should not be abrupt
Interaction
- Metabolized in the liver
- Increased maintenance dose if co-administered with liver enzyme inducers
- Possible reduction of maintenance dose if co-administered with liver enzyme inhibitors
Contraindications
- Hypersensitivity to the product or its ingredients
- Patients receiving live virus immunization
Side Effects
- GI disturbances
- Musculoskeletal effects
- Endocrine effects
- Neuropsychiatric effects
- Ophthalmic effects
- Fluid and electrolyte disturbances
- Increased susceptibility to infection
- Impaired healing
- Hypersensitivity reactions
- Skin atrophy
- Striae
- Telangiectasia
- Acne
- Myocardial rupture following recent MI
- Thromboembolism
Pregnancy & Lactation
- Placental crossing
- Potential risk of intrauterine growth retardation
- Excretion in breast milk
- Unlikely systemic effects in the infant for doses up to 50 mg daily
- Possible adrenal suppression for infants of mothers taking higher doses
Precautions & Warnings
- Special caution for cardiac disease or congestive heart failure
- Salt and water retention risk
- Potassium supplementation may be necessary
- Caution in gastritis, oesophagitis, diverticulitis, ulcerative colitis
- Diabetes mellitus
- Osteoporosis
- Myasthenia gravis
- Renal insufficiency
- Psychotic tendency
- Corticosteroid-induced myopathy
- Liver failure
- Hypothyroidism and cirrhosis
- Ocular herpes simplex
Use in Special Populations
- Increased blood levels in hepatic impairment
- Monitoring and adjustment in hepatic impairment
- No special precautions in renally impaired patients
- No special precautions for elderly patients
Therapeutic Class
- Glucocorticoids
Storage Conditions
- Cool and dry storage below 25°C
- Protection from light and moisture
- Keep out of the reach of children