Zopanib 200 mg (Tablet)

Unit Price: ৳ 371.20 (3 x 10: ৳ 11,136.00)
Strip Price: ৳ 3,712.00

Medicine Details

Category Details
Generic Pazopanib hydrochloride
Company Beacon pharmaceuticals plc
Also available as
Zopanib 400 mg tablet

Indications

  • Treatment of advanced renal cell carcinoma (RCC)
  • Treatment of advanced soft tissue sarcoma (STS)
  • Prior chemotherapy for advanced STS
  • Efficacy in adipocytic STS or gastrointestinal stromal tumors not demonstrated

Pharmacology

  • Multi-tyrosine kinase inhibitor
  • Inhibition of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-α and -β, FGFR-1 and -3, Kit, Itk, Lck, c-Fms
  • Absorption time: 2 to 4 hours
  • Binding to human plasma protein > 99%
  • Metabolized by CYP3A4, minor contribution from CYP1A2 and CYP2C8
  • Mean half-life: 30.9 hours

Dosage & Administration

  • Recommended starting dose: 800 mg orally once daily
  • Should not exceed 800 mg
  • Tablets should not be crushed
  • Missed dose timing
  • Directed by registered physicians

Interaction

  • Inhibitors and inducers of CYP3A4 may alter metabolism
  • Avoid strong CYP3A4 inhibitors like Ketoconazole, Ritonavir, Clarithromycin
  • Avoid Grapefruit or grapefruit juice
  • CYP3A4 inducers like Rifampin may decrease plasma concentrations
  • Substrate of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP)
  • Weak inhibitor of CYP3A4, CYP2C8, and CYP2D6

Contraindications

  • Known hypersensitivity to Pazopanib or any other components of this product

Side Effects

  • Hepatic Toxicity and Hepatic Impairment
  • QT Prolongation and Torsades de Pointes
  • Cardiac Dysfunction
  • Hemorrhagic Events
  • Thromboembolic Events
  • Gastrointestinal Perforation and Fistula
  • Interstitial Lung Disease/Pneumonitis
  • Hypertension
  • Hypothyroidism
  • Proteinuria
  • Tumor Lysis Syndrome
  • Infection
  • Increased Toxicity with Other Cancer Therapy

Pregnancy & Lactation

  • Can cause fetal harm
  • No available data in pregnant women
  • Women should be advised of potential risk to fetus
  • No information regarding presence in human milk or effects on the breastfed infant

Precautions & Warnings

  • Hepatic Toxicity and Hepatic Impairment
  • QT Prolongation and Torsades De Pointes
  • Baseline and periodic monitoring of ECGs
  • Maintenance of electrolytes within the normal range

Use in Special Populations

  • Females: Use effective contraception during treatment and for at least 2 weeks after the last dose
  • Males: Use condoms during treatment with Zopanib and for at least 2 weeks after the last dose
  • Pediatric use not established

Overdose Effects

  • Dose-limiting toxicities observed in clinical trials
  • Treatment of overdose with general supportive measures
  • No specific antidote for overdosage

Storage Conditions

  • Store below 30°C in a cool and dry place
  • Keep out of reach of children

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