Zopanib 400 mg (Tablet)
Unit Price: ৳ 696.00 (2 x 10: ৳ 13,920.00)
Strip Price: ৳ 6,960.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pazopanib hydrochloride |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- advanced renal cell carcinoma (RCC)
- advanced soft tissue sarcoma (STS)
- adipocytic STS
- gastrointestinal stromal tumors
Pharmacology
- multi-tyrosine kinase inhibitor
- VEGFR-1
- VEGFR-2
- VEGFR-3
- PDGFR-α
- PDGFR-β
- FGFR-1
- FGFR-3
- CYP3A4 metabolism
- half-life of 30.9 hours
Dosage & Administration
- recommended starting dose of 800 mg orally once daily without food
- should not exceed 800 mg
- tablet should not be crushed
- missed dose
- oral absorption with median time to peak concentrations of 2 to 4 hours
Interaction
- CYP3A4 inhibitors
- CYP3A4 inducers
- inhibitors of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP)
- weak inhibitor of CYP3A4, CYP2C8, and CYP2D6
- interaction with Simvastatin
Contraindications
- known hypersensitivity to Pazopanib
Side Effects
- hepatic toxicity
- QT prolongation
- cardiac dysfunction
- hemorrhagic events
- thromboembolic events
- gastrointestinal perforation
- pneumonitis
- hypertension
- hypothyroidism
- proteinuria
- tumor lysis syndrome
- infection
Pregnancy & Lactation
- fetal harm
- advice for pregnant women
- advice for lactating women
Precautions & Warnings
- hepatotoxicity
- transaminase elevations
- QT interval prolongation
- Torsades de pointes
Use in Special Populations
- females
- males
- pediatric use
Overdose Effects
- dose-limiting toxicity
- supportive measures
- lack of specific antidote
Storage Conditions
- Store below 30°C
- cool and dry place
- away from sunlight
- keep out of reach of children