Dysmen 250 mg (Tablet)

Indications

• Fever
• Toothache
• Headache
• Migraine
• Primary dysmenorrhoea
• Menorrhagia
• Mild to moderate pain in rheumatoid arthritis and osteoarthritis
• Traumatic pain
• Low-back pain
• Juvenile chronic arthritis in children

Pharmacology

Mefenamic acid contains Mefenamic Acid which is a nonsteroidal agent with demonstrated analgesic, anti-inflammatory and antipyretic activity due to its dual action on prostaglandins. It inhibits the enzymes of prostaglandin synthetase and also antagonizes the actions of prostaglandin at the receptor sites.

Dosage & Administration

• Adult:
  • 500 mg dose should be given to adults upto three times (1.5 gm total) per day with meals. The dosage may be reduced to 1 tablet (250 mg) three times daily.
  • In case of menorrhagia: 500 mg three times daily with meals and from the onset of menses and continued according to the judgement of the physician.
• Children:
  • 6 months to 1 year: 5 ml three times/day.
  • 2-4 years: 10 ml three times/day.
  • 5-8 years: 10 ml four times /day.
  • 9-12 years: 15 ml four times/day.
• Treatment duration: Not to be continued for more than 7 days except on the advice of a physician.

Interaction

• Aspirin: Concomitant administration of Dysmen and Aspirin is not generally recommended because of the potential of increased adverse effects.
• Warfarin: Dysmen can inhibit platelet aggregation and may prolong the prothrombin time in patients on warfarin therapy

Contraindications

Patients with known hypersensitivity to Mefenamic Acid, peptic ulcer, inflammatory bowel diseases, hepatic or renal impairment. Also contraindicated in patients with bronchospasm or skin rashes induced by aspirin and/or other NSAIDs.

Side Effects

• Abdominal pain
• Constipation
• Diarrhoea
• Dyspepsia
• Flatulence
• Nausea
• GI ulcers
• Vomiting
• Dizziness
• Abnormal renal function
• Pruritus
• Rashes

Pregnancy & Lactation

Mefenamic acid should be used in women of childbearing potential and during pregnancy only when the potential benefits are expected to outweigh the potential risks. It should not be taken by nursing mothers.

Precautions & Warnings

Administer with caution in allergic diseases especially in asthma. Withdraw treatment in case of diarrhoea, rashes, cholestatic jaundice, thrombocytopenia, haemolytic anaemia.

Therapeutic Class

• Drugs for Osteoarthritis
• Drugs used for Rheumatoid Arthritis
• Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Keep away from light, store in a cool and dry place. Keep out of reach of children.

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