Accuzith 500 mg (Tablet)

Unit Price: ৳ 55.00 (2 x 3: ৳ 330.00)
Strip Price: ৳ 165.00

Medicine Details

Category Details
Generic Azithromycin dihydrate
Company Dbl pharmaceuticals ltd
Also available as
Accuzith 200 mg suspension

Title

  • Accuzith 500 mg Tablet

Categories

  • Medicine
  • Healthcare
  • Pharmaceutical

Description

  • Accuzith is indicated for infections in lower respiratory tract, upper respiratory tract, otitis media, and skin and soft tissue infections. It is also indicated in the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis. Azithromycin, the active ingredient, is acid-stable and can be taken orally without protection from gastric acids. It has high concentrations in phagocytes, facilitating transport to the site of infection. Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms, interfering with microbial protein synthesis without affecting nucleic acid synthesis.

Dosage

  • Oral Adult: 500 mg once daily for 3 days or 500 mg on day 1, then 250 mg daily for 4 days. For sexually transmitted diseases, the dose is 1 gm as a single dose or 500 mg on day 1, followed by 250 mg daily for 2 days. Children: 10 mg/kg body weight once daily for 3 days for children over 6 months.

Administration

  • Reconstitution procedure of suspension: Shake well, add water up to the mark, and shake until powder is completely mixed with water.

Interaction

  • Azithromycin and antacids should be taken at least 1 hour apart. Caution should be exercised when co-administering azithromycin and cyclosporin, digoxin, ergot derivatives, methylprednisolone, theophylline, warfarin, and terfenadine. Azithromycin had no significant effect on the plasma levels of carbamazepine.

Contraindications

  • Hypersensitivity to azithromycin or any other macrolide antibiotic. Co-administration of ergot derivatives and azithromycin. Patients with hepatic diseases.

Side Effects

  • Gastrointestinal side-effects (nausea, vomiting, diarrhoea, abdominal discomfort), allergic reactions, reversible elevations in liver transaminases, cholestatic jaundice, transient mild reductions in neutrophil counts, reversible hearing impairment with prolonged higher doses.

Pregnancy & Lactation

  • Pregnancy Category B. Caution advised during pregnancy and lactation, with use only if adequate alternatives are not available.

Precautions & Warnings

  • Rare serious allergic reactions reported. Caution in renal impairment, avoidance in severe hepatic impairment.

Overdose Effects

  • Typical symptoms include hearing loss, severe nausea, vomiting, and diarrhea. Gastric lavage and supportive measures are indicated.

Storage Conditions

  • Keep in a dry place away from light and heat, out of the reach of children.

Chemical Structure

  • Molecular Formula: C38H72N2O12

Indications

  • Lower respiratory tract infections including bronchitis and pneumonia, upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis, otitis media, skin and soft tissue infections, and sexually transmitted diseases in men and women for the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis.

Pharmacology

  • Azithromycin is acid-stable, absorbed rapidly, and has high tissue concentration due to ion trapping and high lipid solubility. Its half-life allows for large single doses while maintaining bacteriostatic levels in infected tissue for several days. Mechanism of action involves binding to the 50S ribosomal subunit of susceptible microorganisms, interfering with microbial protein synthesis without affecting nucleic acid synthesis.

Use in Renal Impairment

  • No dose adjustment needed in patients with mild renal impairment; caution in more severe renal impairment.

Use in Hepatic Impairment

  • Avoid use in patients with hepatic disease as the liver is the principal route of excretion of azithromycin.

Effect on Ability to Drive and Use Machines

  • No evidence to suggest an effect on a patient’s ability to drive or operate machinery.

Common Questions

  • What is Accuzith 500 mg Tablet?
  • What are the uses of Accuzith 500 mg Tablet?
  • What are the Side Effects of Accuzith 500 mg Tablet?
  • What are the instructions for storage and disposal Accuzith 500 mg Tablet?
  • Can the use of Accuzith 500 mg Tablet cause diarrhea?
  • Is Accuzith 500 mg Tablet safe?
  • Is Accuzith 500 mg Tablet an antibiotic?
  • What if I don't get better even after taking Accuzith 500 mg Tablet?
  • Quick Tips: Do not skip any doses, take tablet 1 hour before or two hours after food, do not take antacids 2 hours before or after the tablet, and stop taking it and consult your doctor if you develop an itchy rash or breathing difficulties.

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