Clopirel 75 mg (Tablet)
Unit Price: ৳ 10.00 (30's pack: ৳ 300.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clopidogrel bisulphate |
| Company | Novo healthcare and pharma ltd |
Indications
- Reduction of myocardial infarction rate
- Reduction of stroke rate
- Treatment for non-ST-segment elevation ACS
- Treatment for acute ST-elevation myocardial infarction
- Treatment for recent MI
- Treatment for recent stroke
- Treatment for established peripheral arterial disease
Pharmacology
- Irreversible binding to P2Y12 class of ADP receptors
- Dose-dependent inhibition of platelet aggregation
- Platelet aggregation inhibition after 2 hours of dose
- Steady state inhibition between Day 3 and Day 7
Dosage & Administration
- 300 mg oral loading dose for acute coronary syndrome
- 75 mg once daily without loading dose for recent MI, recent stroke, or established peripheral arterial disease
- Can be given with or without food
Interaction
- Increased bleeding risk with NSAIDs, warfarin, SSRIs, SNRIs
- Avoid concomitant use with CYP2C19 inhibitors (omeprazole or esomeprazole)
- Avoid concomitant use with Repaglinide as it increases plasma concentrations of Repaglinide
Contraindications
- Hypersensitivity to drug
- Active pathological bleeding such as peptic ulcer or intracranial hemorrhage
Side Effects
- Common: Bleeding, Diarrhoea, gastrointestinal discomfort, haemorrhage, Skin reactions
- Rare: Acquired haemophilia, anaemia, angioedema, arthralgia, arthritis, bone marrow disorders
Pregnancy & Lactation
- Use during pregnancy only if clearly needed
- Unknown excretion in human breast milk
- Consideration for discontinuing nursing or the drug based on importance to the mother
Precautions & Warnings
- Impaired metabolism with CYP2C19 genetic variations
- Increased risk of bleeding
- Restoration of hemostasis with platelet transfusions
- Discontinuation increases risk of cardiovascular events
- Reports of Thrombotic Thrombocytopenic Purpura (TTP)
- Reports of hypersensitivity
Use in Special Populations
- Safety and effectiveness not established in pediatric populations
- No dosage adjustment necessary in elderly patients
Overdose Effects
- May lead to bleeding complications
- Platelet transfusion may restore clotting ability
Therapeutic Class
- Anti-platelet drugs
Storage Conditions
- Keep below 30°C in a dry place
- Protected from light
- Do not freeze
- Keep out of reach of children