CoxTop 120 mg (Tablet)

Unit Price: ৳ 14.00 (2 x 10: ৳ 280.00)
Strip Price: ৳ 140.00

Medicine Details

Category Details
Generic Etoricoxib
Company Al madina pharmaceuticals ltd
Also available as
Coxtop 60 mg tablet Coxtop 90 mg tablet

Title

  • CoxTop 120 mg Tablet

Categories

  • Medicine
  • Pharmaceutical
  • Pain Relief
  • Anti-inflammatory

Indications

  • Osteoarthritis (OA)
  • Rheumatoid arthritis (RA)
  • Ankylosing spondylitis
  • Acute gouty arthritis
  • Dental surgery pain

Pharmacology

  • Potent COX-2 specific inhibitor
  • Inhibition of COX-2 decreases clinical signs and symptoms
  • Decreased potential for GI toxicity
  • Dose-dependent COX-2 inhibition without COX-1 inhibition

Dosage & Administration

  • 30 mg once daily for Osteoarthritis
  • 90 mg once daily for Rheumatoid arthritis and Ankylosing spondylitis
  • 120 mg once daily for Acute gouty arthritis
  • 90 mg once daily for Postoperative dental surgery pain
  • Shortest duration and lowest effective daily dose recommended

Interaction

  • Increase in prothrombin time with oral anticoagulants
  • Reduction in effect of diuretics and antihypertensive drugs with NSAIDs
  • Concomitant use with low-dose acetylsalicylic acid for cardiovascular prophylaxis
  • Potential increase in nephrotoxic effect with ciclosporin or tacrolimus
  • Decrease in lithium renal excretion with NSAIDs

Contraindications

  • Hypersensitivity to active substance or excipients
  • Active peptic ulceration or active GI bleeding
  • Bronchospasm, acute rhinitis, nasal polyps, allergic-type reactions after taking acetylsalicylic acid or NSAIDs
  • Pregnancy and lactation
  • Severe hepatic dysfunction
  • Estimated renal creatinine clearance <30 ml/min
  • Children and adolescents under 16 years of age
  • Inflammatory bowel disease
  • Congestive heart failure
  • Uncontrolled hypertension
  • Established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease

Side Effects

  • Palpitation
  • Fatigue
  • Influenza-like symptoms
  • Ecchymosis
  • Dry mouth
  • Taste disturbance
  • Mouth ulcer
  • Atrial fibrillation
  • Transient ischaemic attack
  • Chest pain
  • Flushing
  • Cough
  • Dyspnoea
  • Epistaxis
  • Anxiety
  • Impaired mental acuity
  • Paraesthesia
  • Electrolyte disturbance
  • Myalgia
  • Arthralgia
  • Confusion
  • Hallucinations

Pregnancy & Lactation

  • Not recommended in women attempting to conceive
  • Excretion in lactating rats
  • Not recommended for breastfeeding women

Precautions & Warnings

  • Caution in patients at risk of GI complications with NSAIDs
  • Consideration for patients with significant cardiovascular risk factors
  • Monitoring of renal function in patients with reduced prostaglandin formation
  • Caution in patients with history of cardiac failure, left ventricular dysfunction, or hypertension
  • Monitoring for liver dysfunction and signs of hypersensitivity
  • Caution when co-administering with warfarin or other oral anticoagulants

Overdose Effects

  • No significant toxicity up to 500 mg single dose
  • Supportive measures in case of overdose

Therapeutic Class

  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C18H15ClN2O2S

Common Questions about CoxTop 120 mg Tablet

  • Selective COX-2 inhibitor
  • Duration of effect: 20-24 hours
  • Onset of action: 1-2 hours; faster without food
  • Pregnancy warnings
  • No habit forming tendencies
  • Not recommended for breastfeeding mothers
  • Unsafe to consume with alcohol
  • May affect alertness; avoid driving
  • Caution in patient with kidney disease
  • Caution in patient with liver disease

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