Flumazole 150 mg (Capsule)
Unit Price: ৳ 20.00 (1 x 10: ৳ 200.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Al madina pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
- Triazole antifungal agent
- Potent inhibitor of fungal cytochrome P-450 dependent enzymes
- Responsible for the synthesis of ergosterol
- Essential component of fungal cell membrane
Dosage administration
- Dosage for Vaginal Candidiasis: 150 mg as a single dose for adults
- Dosage for Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days for adults
- Dosage for Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days for adults
- Dosage for Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks for adults
- Dosage for Kerion: 50 mg daily for 20 days for adults
- Dosage for Pityriasis versicolor: 400 mg as a single dose for adults
- Dosage for Onychomycosis: 150 mg weekly for 12 months for adults
- Dosage for Invasive candidal infections and cryptococcal infections: Orally or by IV infusion, 400 mg on first day then 200-400 mg daily for adults
- Dosage for Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily for adults
- Dosage for Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily for adults
- Dosage for children over 1 year: 1-2 mg/kg daily for Superficial Candidiasis
- Dosage for children over 1 year: 3-6 mg/kg daily for Systemic Candidiasis & Cryptococcal infection
Interaction
- Increased prothrombin time after warfarin administration
- Prolonged serum half-life of concomitantly administered oral sulphonylureas
- Effect of co-administration of hydrochlorothiazide to healthy volunteers
- Increased level of phenytoin with co-administration of fluconazole
- Decrease in AUC and shorter half-life with co-administration of rifampicin
- No relevant effects on hormone level with combined oral contraceptives
- Slowly increased cyclosporin concentrations in renal transplant patients
- No clinically significant impairment of fluconazole absorption with food, cemetidine, antacids
Contraindications
- Known hypersensitivity to Fluconazole or to related triazole compounds
Side effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Flatulence
- Rash (Incidence less than 1%)
- Anaphylaxis (rare)
Pregnancy lactation
- Adverse fetal effects seen in animals at high dose levels
- Not recommended in pregnancy or in women of childbearing potential
- Similar concentrations in human breast milk as in plasma
Precautions warnings
- Observation of abnormalities in hepatic, renal, haematological and other biochemical function tests in some patients
- Rarely observed exfoliative cutaneous reactions
- Discontinue therapy if rash develops in patients treated for superficial fungal infection
- Not recommended for use during lactation
- Unlikely to impair ability to drive or use machinery
Use in special populations
- Normal dose for use in the elderly if no evidence of renal impairment
- Dosage interval or daily dosage modification in patients with renal impairment
- Excreted predominantly in the urine as unchanged drug
Overdose effects
- Supportive measures and symptomatic treatment with gastric lavage if necessary
- Excreted largely in the urine
- Forced volume diuresis may increase the elimination rate
- Three-hour session of hemodialysis decreases plasma levels by approximately 50%
Therapeutic class
- Drugs for subcutaneous and mycoses
Storage conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children