Epicet XR 500 mg (Tablet (Extended Release))
Unit Price: ৳ 30.00 (2 x 6: ৳ 360.00)
Strip Price: ৳ 180.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Levetiracetam |
| Company | Renata limited |
| Also available as |
Indications
- Partial-onset seizures treatment
- Monotherapy
- Adjunctive therapy
- Treatment for newly diagnosed epilepsy
- Treatment for myoclonic seizures
- Treatment for primary generalized tonic-clonic seizures
Description
- Precise mechanism is unknown
- Minimal activity in submaximal stimulation
- Inhibition of burst firing
- Selective prevention of hyper synchronization of epileptiform burst firing
Dosage
- Recommended starting dose for adults and adolescents
- Initial therapeutic dose
- Maximum dose for adults
- Maximum dose for pediatric population
- Dosage adjustments for renal impairment
- Oral solution for children under 6 years
- Monotherapy safety and efficacy under 16 years not established
- Lowest effective dose should be used for children
Administration
- Oral administration
- Swallow with liquid
- Can be taken with or without food
- Divided in two equal doses
Interaction
- No influence on serum concentrations of existing antiepileptic drugs
- Inhibition of renal clearance of primary metabolite by probenecid
- Decrease in methotrexate clearance when administered concomitantly
- Reports of decreased efficacy when co-administered with osmotic laxative
- No alteration of absorption by food
Contraindications
- Hypersensitivity to active substance or pyrrolidone derivatives
Side Effects
- Most common adverse reactions in adults
- Most common adverse reactions in pediatric patients
Pregnancy & Lactation
- Not recommended during pregnancy
- Not recommended during breastfeeding
- Impact on fertility not detected in animal studies
Precautions & Warnings
- Dose adjustment for renal impairment
- Rare cases of decreased blood cell counts
- Risk of suicidal thoughts and behavior
- Tablet formulation not adapted for infants and children under 6 years
Use in Special Populations
- Dose adjustment in elderly patients with compromised renal function
- Individualized dose according to renal function
- No dose adjustment for mild to moderate hepatic impairment
- 50% reduction of daily maintenance dose for severe hepatic impairment
Overdose Effects
- Observed effects of overdoses
- No specific antidote
- Symptomatic treatment
- Possible haemodialysis
Therapeutic Class
- Adjunct anti-epileptic drugs
Storage Conditions
- Store at cool temperature
- Protect from light