Diliner DR 20 mg (Capsule (Delayed Release))
Unit Price: ৳ 8.00 (5 x 6: ৳ 240.00)
Strip Price: ৳ 48.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Duloxetine hydrochloride |
| Company | Square pharmaceuticals plc |
| Also available as |
Title
- Diliner DR Serotonin and Norepinephrine Reuptake Inhibitor (SNRI)
Categories
- Antidepressant
- Antianxiety
- Pain Management
Description
- Oral administration
- Less potent inhibitor of dopamine reuptake
- Well absorbed through hepatic metabolism
Indications
- Major Depressive Disorder (MDD)
- Generalized Anxiety Disorder (GAD)
- Diabetic Peripheral Neuropathic Pain (DPNP)
- Fibromyalgia
- Chronic Musculoskeletal Pain
Pharmacology
- Selective serotonin and norepinephrine reuptake inhibitor (SSNRI)
- No significant affinity for various receptors
- No inhibition of monoamine oxidase (MAO)
Dosage & Administration
- Starting Dose: 30-60 mg/day
- Target Dose: 30-60 mg/day for various conditions
- Maximum Dose: 120 mg/day
Interaction
- Metabolism via CYP1A2 and CYP2D6 isozymes
- Inhibition by fluvoxamine and similar drugs
- Higher concentrations with potent CYP2D6 inhibitors
Contraindications
- Known hypersensitivity to the drug or inactive ingredients
- Not approved for treating bipolar depression
- Not for patients with substantial alcohol use or chronic liver disease
- Cautious use in patients with controlled narrow-angle glaucoma
Side Effects
- Nausea
- Dizziness
- Dry mouth
- Constipation
- Decreased appetite
- Fatigue
- Somnolence
- Increased sweating
- Hyperhidrosis
- Asthenia
- Slight increase in blood pressure
Pregnancy & Lactation
- Pregnancy Category C
- Use during pregnancy if potential benefit justifies potential risk to fetus
- Unknown effects on labor and delivery
- Not recommended during nursing
Precautions & Warnings
- Close monitoring for clinical worsening and suicidality
- Blood pressure measurement prior to treatment and periodically
- Caution with concomitant use of NSAIDs, aspirin, or other coagulation-affecting drugs
- Cautious use in patients with history of mania or seizure disorder
Use in Special Populations
- Safety and efficacy not established in pediatric patients
Overdose Effects
- Limited clinical experience with overdose
- No specific antidote
- General measures for overdose management
- Assurance of adequate airway, oxygenation, and ventilation
- Monitoring of cardiac rhythm and vital signs
- Avoidance of emesis induction
- Possible use of activated charcoal
Therapeutic Class
- Serotonin-norepinephrine reuptake inhibitor (SNRI)
Storage Conditions
- Do not store above 30°C
- Keep away from light and out of the reach of children