Diliner DR 20 mg (Capsule (Delayed Release))

Unit Price: ৳ 8.00 (5 x 6: ৳ 240.00)
Strip Price: ৳ 48.00

Medicine Details

Category Details
Generic Duloxetine hydrochloride
Company Square pharmaceuticals plc
Also available as
Diliner dr 60 mg dr capsule

Title

  • Diliner DR Serotonin and Norepinephrine Reuptake Inhibitor (SNRI)

Categories

  • Antidepressant
  • Antianxiety
  • Pain Management

Description

  • Oral administration
  • Less potent inhibitor of dopamine reuptake
  • Well absorbed through hepatic metabolism

Indications

  • Major Depressive Disorder (MDD)
  • Generalized Anxiety Disorder (GAD)
  • Diabetic Peripheral Neuropathic Pain (DPNP)
  • Fibromyalgia
  • Chronic Musculoskeletal Pain

Pharmacology

  • Selective serotonin and norepinephrine reuptake inhibitor (SSNRI)
  • No significant affinity for various receptors
  • No inhibition of monoamine oxidase (MAO)

Dosage & Administration

  • Starting Dose: 30-60 mg/day
  • Target Dose: 30-60 mg/day for various conditions
  • Maximum Dose: 120 mg/day

Interaction

  • Metabolism via CYP1A2 and CYP2D6 isozymes
  • Inhibition by fluvoxamine and similar drugs
  • Higher concentrations with potent CYP2D6 inhibitors

Contraindications

  • Known hypersensitivity to the drug or inactive ingredients
  • Not approved for treating bipolar depression
  • Not for patients with substantial alcohol use or chronic liver disease
  • Cautious use in patients with controlled narrow-angle glaucoma

Side Effects

  • Nausea
  • Dizziness
  • Dry mouth
  • Constipation
  • Decreased appetite
  • Fatigue
  • Somnolence
  • Increased sweating
  • Hyperhidrosis
  • Asthenia
  • Slight increase in blood pressure

Pregnancy & Lactation

  • Pregnancy Category C
  • Use during pregnancy if potential benefit justifies potential risk to fetus
  • Unknown effects on labor and delivery
  • Not recommended during nursing

Precautions & Warnings

  • Close monitoring for clinical worsening and suicidality
  • Blood pressure measurement prior to treatment and periodically
  • Caution with concomitant use of NSAIDs, aspirin, or other coagulation-affecting drugs
  • Cautious use in patients with history of mania or seizure disorder

Use in Special Populations

  • Safety and efficacy not established in pediatric patients

Overdose Effects

  • Limited clinical experience with overdose
  • No specific antidote
  • General measures for overdose management
  • Assurance of adequate airway, oxygenation, and ventilation
  • Monitoring of cardiac rhythm and vital signs
  • Avoidance of emesis induction
  • Possible use of activated charcoal

Therapeutic Class

  • Serotonin-norepinephrine reuptake inhibitor (SNRI)

Storage Conditions

  • Do not store above 30°C
  • Keep away from light and out of the reach of children

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