Benazin 12.5 mg (Tablet)
Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tetrabenazine |
| Company | Renata limited |
| Also available as |
Indications
- Treatment of chorea associated with Huntington's disease
Pharmacology
- Vesicular monoamine transporter-2 (VMAT-2) inhibitor
Dosage & Administration
- Can be taken with or without food
- Individualization of dose with careful weekly titration required
- Pediatric & geriatric use not established
Interaction
- Strong CYP2D6 Inhibitors can require reduction in dose
- Reserpine should not be used concomitantly
- No interaction with food
Contraindications
- Actively suicidal, untreated or undertreated depression
- Hepatic impairment
- Concurrent use of monoamine oxidase inhibitors (MAOIs) or reserpine
- Concurrent use of deutetrabenazine or valbenazine
Side Effects
- Common adverse reactions: sedation/somnolence, fatigue, insomnia, depression, akathisia, anxiety/anxiety aggravated, nausea
- Rare adverse reactions: suicidal thoughts, neuroleptic malignant syndrome, pneumonia
Pregnancy & Lactation
- No adequate data on developmental risk in pregnant women
- No data on presence in human milk
Precautions & Warnings
- Maximum daily dose should not exceed 50 mg/day
- Maximum single dose should not exceed 25 mg if administered with a strong CYP2D6 inhibitor
- Potential for adverse effects should be periodically re-evaluated
- Use cautiously in combination with drugs that prolong QTc
Overdose Effects
- Signs and symptoms may include drowsiness, sweating, hypothermia
Therapeutic Class
- Atypical neuroleptic drugs
Storage Conditions
- Store in a cool & dry place
- Protect from light & moisture
- Keep out of reach of children