Mitadip 30 mg (Tablet)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Mirtazapine |
| Company | Renata limited |
| Also available as |
Indications
- Treatment of major depressive disorder (MDD)
Pharmacology
- Enhances central noradrenergic and serotonergic activity
- Acts as an antagonist at central presynaptic α2-adrenergic inhibitory autoreceptors and heteroreceptors
- Potent antagonist of 5-HT2 and 5-HT3 receptors
- Moderate peripheral α1-adrenergic antagonist
- Moderate antagonist at muscarinic receptors
- Potent antagonist of histamine (H1) receptors
Pharmacokinetics
- Rapid and well-absorbed after oral administration
- Reaches peak plasma levels after about 2 hours
- Mean half-life of elimination is 20-40 hours
- Displays linear pharmacokinetics within the recommended dose range
- Extensively metabolized and eliminated via urine and faeces
Dosage & Administration
- Recommended starting dose: 15 mg/day
- Effective dose range: 15 to 45 mg/day
- Half-life of elimination justifies once-a-day dosing
- Dose changes should be made at intervals of less than 1 to 2 weeks
- Not recommended for use in children
Interaction
- Clinically significant drug-drug interactions with MAOI and other serotonergic drugs
- May interrupt the metabolism or activity of Carbamazepine, Phenytoin, or Cimetidine
- Patient should avoid Alcohol & Diazepam while taking Mitadip
Contraindications
- Contraindicated in patients with known hypersensitivity to Mirtazapine or excipients
- Concomitant use with MAO inhibitor is contraindicated
Side Effects
- Dizziness
- Drowsiness
- Dry mouth
- Increased appetite
- Weight gain
Pregnancy & Lactation
- Pregnancy Category-C
- Patients should notify their physician if they become pregnant or intend to become pregnant during therapy
- Patients should notify their physician if they are breastfeeding
Precautions & Warnings
- Patients and caregivers should be alert to the emergence of certain behavioral changes
- Patients should be warned about the risk of developing agranulocytosis
- May impair judgment, thinking, and motor skills
- Clinically significant ALT (SGPT) elevations may occur
Therapeutic Class
- Atypical anti-depressant drugs
Storage Conditions
- Keep away from light and moisture
- Store below 30°C
- Keep all medicine out of the reach of children