Twindopa 250 mg+25 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Levodopa carbidopa fc tablet |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Parkinson's disease treatment
- Symptoms relief
- Rigidity relief
- Bradykinesia relief
- Tremor management
- Dysphagia management
- Sialorrhea management
- Postural instability management
- Motor recovery after stroke support
Description
- Levodopa precursor of dopamine
- Blood-brain barrier crossing
- Dopamine conversion in brain
- Carbidopa DDC inhibitor
- Peripheral metabolism reduction
- Increased Levodopa availability to brain
Dosage & Administration
- Initial 100/10 mg tablet dosage
- Titration for optimal carbidopa dosage
- Starting dosage for 250/25 mg tablet
- Maintenance dosage individualization
- Substitution with 250/25 mg tablet
- Experience with daily dosage greater than 200 mg limited
Interaction
- Symptomatic postural hypotension risk
- Antihypertensive medicine dosage adjustment
- Rare reports of adverse reactions with tricyclic antidepressants
- Bioavailability decrease when ingested with ferrous sulphate
- Therapeutic effects reduction with dopamine-2 receptor antagonists and isoniazid
- Loss of therapeutic response with phenytoin and papaverine
Contraindications
- Hypersensitivity to Carbidopa and Levodopa
- Narrow-angle glaucoma presence
- Risk of activating malignant melanoma
Side Effects
- Central neuropharmacologic activity related reactions
- Dosage reduction for diminished reactions
- Frequent adverse effects: dyskinesias, nausea
- Various adverse effects categories: body, cardiovascular, gastrointestinal, haemotologic, hypersensitivity, nervous system, respiratory, skin, urogenital
Pregnancy & Lactation
- Effects on human pregnancy unknown
- Visceral and skeletal malformations in rabbits
- Careful consideration for use in women of childbearing potential
- Unknown excretion in human milk
- Weighting benefits against possible hazards for nursing mothers
Precautions & Warnings
- Not recommended for medicine-induced extrapyramidal reactions
- Initial Levodopa discontinuation before Carbidopa-Levodopa use
- Observation for depression and suicidal tendencies
- Caution in patients with severe cardiovascular or pulmonary disease, renal, hepatic or endocrine disease, or a history of peptic ulcer
- Monitoring for changes in intraocular pressure
Use in Special Populations
- Not recommended for patients below 18 years
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Cool and dry place storage
- Protection from light