Neurocet XR 750 mg (Tablet (Extended Release))

Unit Price: ৳ 40.00 (2 x 10: ৳ 800.00)
Strip Price: ৳ 400.00

Medicine Details

Category Details
Generic Levetiracetam
Company Incepta pharmaceuticals ltd
Also available as
Neurocet 250 mg tablet Neurocet 500 mg tablet Neurocet 500 mg oral solution Neurocet 500 mg injection Neurocet xr 500 mg tablet

Indications

  • Monotherapy in the treatment of partial-onset seizures
  • Adjunctive therapy in the treatment of myoclonic seizures
  • Adjunctive therapy in the treatment of primary generalized tonic-clonic seizures
  • Treatment of epilepsy in adults and adolescents
  • Treatment of epilepsy in children and infants from 1 month of age

Mechanism of Action

  • Precise mechanism(s) unknown
  • Minimal activity in submaximal stimulation
  • Protection against secondarily generalized activity
  • Inhibition of burst firing
  • Selective prevention of hyper synchronization

Dosage

  • Recommended starting dose of 250 mg twice daily for adults and adolescents from 16 years of age
  • Maximum dose of 1500 mg twice daily for adults and adolescents
  • Dose adjustments for pediatric population based on weight and age
  • Use of oral solution for infants and children under 6 years

Administration

  • Oral administration
  • Swallowed with a sufficient quantity of liquid
  • Administered in two equally divided doses
  • Can be taken with or without food

Interaction

  • No influence on serum concentrations of existing antiepileptic medicinal products
  • Inhibition of renal clearance by probenecid
  • Decrease in methotrexate clearance
  • Decreased efficacy with concomitant use of osmotic laxative macrogol
  • No alteration of absorption by food, but reduced rate of absorption

Contraindications

  • Hypersensitivity to the active substance or other pyrrolidone derivatives
  • Hypersensitivity to any of the excipients

Side Effects

  • Most common adverse reactions include somnolence, asthenia, infection, dizziness in adults
  • Most common adverse reactions include fatigue, aggression, nasal congestion, decreased appetite, irritability in pediatric patients

Precautions

  • Dose adjustment may be required for patients with renal impairment
  • Association with acute kidney injury
  • Advice for blood cell counts
  • Monitoring for signs of depression and suicidal ideation and behaviors
  • Caution for use in infants and children below 6 years

Pregnancy & Lactation

  • Not recommended during pregnancy and in women of childbearing potential not using contraception
  • Excreted in human breast milk, breastfeeding not recommended

Use in Special Populations

  • Dose adjustment recommended in elderly patients with compromised renal function

Overdose Effects

  • Observation of somnolence, agitation, aggression, depressed level of consciousness, respiratory depression and coma
  • Symptomatic treatment for overdose, including haemodialysis

Therapeutic Class

  • Adjunct anti-epileptic drugs

Storage Conditions

  • Store at a cool temperature not exceeding 25°C
  • Dry place, protected from light

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