Levepro 500 mg (Tablet)

Unit Price: ৳ 30.00 (2 x 10: ৳ 600.00)
Strip Price: ৳ 300.00

Medicine Details

Category Details
Generic Levetiracetam
Company Genvio pharma ltd
Also available as
Levepro 250 mg tablet

Indications

  • Treatment of partial-onset seizures
  • Adjunctive therapy for seizures
  • Treatment of myoclonic seizures
  • Treatment of generalized tonic-clonic seizures

Description

  • Mechanism of antiepileptic effect is unknown
  • Minimal activity in stimulation tests
  • Protection against generalized activity
  • Inhibition of burst firing in hippocampus

Dosage

  • Recommended starting dose for adults and adolescents from 16 years of age
  • Starting dose for adults (≥18 years) and adolescents (12 to 17 years) weighing 50 kg or more
  • Use of oral solution for infants and children under the age of 6 years
  • Safety and efficacy of monotherapy treatment in children and adolescents below 16 years not established

Administration

  • Oral administration
  • Swallowed with sufficient quantity of liquid
  • May be taken with or without food
  • Administered in two equally divided doses

Interaction

  • No influence on serum concentrations of existing antiepileptic medicinal products
  • Effect on methotrexate clearance
  • Reports of decreased efficacy when concomitantly administered with osmotic laxative
  • No alteration in absorption by food, but slightly reduced rate of absorption

Contraindications

  • Hypersensitivity to the active substance or other pyrrolidone derivatives

Side Effects

  • Most common adverse reactions in adult patients
  • Most common adverse reactions in pediatric patients

Pregnancy & Lactation

  • Not recommended during pregnancy
  • Excretion in human breast milk
  • Breastfeeding not recommended
  • No impact on fertility detected in animal studies

Precautions & Warnings

  • Dose adjustment for patients with renal impairment
  • Association with acute kidney injury
  • Cases of decreased blood cell counts
  • Reported cases of suicide, suicidal ideation and behavior
  • Not adapted for use in infants and children under the age of 6 years

Use in Special Populations

  • Dose adjustment recommendation for elderly patients with compromised renal function
  • Individualized daily dose according to renal function
  • No dose adjustment for patients with mild to moderate hepatic impairment
  • Dose reduction recommendation for severe hepatic impairment

Overdose Effects

  • Observation of somnolence, agitation, aggression, and respiratory depression
  • No specific antidote
  • Symptomatic treatment with potential haemodialysis

Therapeutic Class

  • Adjunct anti-epileptic drugs

Storage Conditions

  • Store at a cool temperature not exceeding 25°C
  • Store in a dry place
  • Protected from light

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