Levepro 250 mg (Tablet)

Unit Price: ৳ 16.00 (3 x 10: ৳ 480.00)
Strip Price: ৳ 160.00

Medicine Details

Category Details
Generic Levetiracetam
Company Genvio pharma ltd
Also available as
Levepro 500 mg tablet

Uses and Administration

  • Monotherapy in the treatment of partial-onset seizures in adults and adolescents from 16 years of age
  • Adjunctive therapy in the treatment of partial-onset seizures in adults, adolescents, children, and infants from 1 month of age with epilepsy
  • Treatment of myoclonic seizures in adults and adolescents from 12 years of age with Juvenile Myoclonic Epilepsy
  • Treatment of primary generalized tonic-clonic seizures in adults and adolescents from 12 years of age with Idiopathic Generalised Epilepsy
  • Oral administration in two equally divided doses daily
  • Preferred oral solution for use in infants and children under the age of 6 years

Dosage and Administration

  • Starting dose of 250 mg twice daily for adults and adolescents from 16 years of age
  • Initial therapeutic dose of 500 mg twice daily for adults and adolescents (≥18 years) weighing 50 kg or more
  • Incremental dosage adjustments based on clinical response
  • Maximum dose of 1500 mg twice daily for adults and adolescents
  • Tablet formulation not adapted for use in infants and children under the age of 6 years

Interaction with Other Medications

  • Minimal influence on serum concentrations of existing antiepileptic medicinal products
  • No influence on the pharmacokinetics of antiepileptic medicinal products
  • Potential interaction with probenecid, methotrexate, and laxatives
  • No alteration of Levepro absorption by food, but a slightly reduced rate

Contraindications

  • Hypersensitivity to the active substance or other pyrrolidone derivatives or to any of the excipients

Side Effects

  • Common adverse reactions include somnolence, asthenia, infection, dizziness in adult patients
  • Common adverse reactions include fatigue, aggression, nasal congestion, decreased appetite, irritability in pediatric patients

Pregnancy and Lactation

  • Not recommended during pregnancy and in women of childbearing potential not using contraception unless clinically necessary
  • Excreted in human breast milk, therefore breastfeeding not recommended

Precautions and Warnings

  • Dose adjustment may be required for patients with renal impairment
  • Rare cases of decreased blood cell counts have been described
  • Possible association with suicide, suicidal ideation, and behavior
  • Long-term effects on growth, puberty, and childbearing potential in children remain unknown

Use in Special Populations

  • Dose adjustment recommended in elderly patients with compromised renal function
  • Dose individualization according to renal function
  • No dose adjustment needed in patients with mild to moderate hepatic impairment

Overdose Effects and Treatment

  • Occurrence of somnolence, agitation, aggression, depressed level of consciousness, respiratory depression, and coma
  • No specific antidote available
  • Symptomatic treatment may include haemodialysis
  • Extraction efficiency of Levepro on dialysis is 60%

Therapeutic Class

  • Adjunct anti-epileptic drugs

Storage Conditions

  • Store at a cool temperature not exceeding 25°C
  • Store in a dry place protected from light

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