Noclog 75 mg (Tablet)

Unit Price: ৳ 12.00 (4 x 10: ৳ 480.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Clopidogrel bisulphate
Company Eskayef pharmaceuticals ltd

Title and Categories

  • Noclog Anti-Platelet Medication
  • Therapeutic Class: Anti-platelet drugs

Indications

  • Reduces the rate of myocardial infarction (MI)
  • Reduces the rate of stroke
  • Indicated for Acute Coronary Syndrome (ACS)
  • Indicated for non-ST-segment elevation ACS
  • Indicated for unstable angina (UA)
  • Indicated for non-ST-elevation myocardial infarction (NSTEMI)
  • Indicated for acute ST-elevation myocardial infarction (STEMI)
  • Indicated for Recent MI, Recent Stroke, or Established Peripheral Arterial Disease
  • Reduces the rate of MI in patients with established peripheral arterial disease
  • Reduces the rate of stroke in patients with established peripheral arterial disease

Pharmacology

  • Clopidogrel is a prodrug
  • Inhibits platelet activation
  • Inhibits platelet aggregation
  • Irreversibly binds to the P2Y12 class of ADP receptors on platelets
  • Dose-dependent inhibition of platelet aggregation
  • Inhibition of platelet aggregation can be seen 2 hours after single oral doses

Dosage & Administration

  • 300 mg oral loading dose for patients who need an antiplatelet effect within hours
  • 75 mg once daily orally for Recent MI, Recent Stroke, or Established Peripheral Arterial Disease
  • Initiating without a loading dose will delay establishment of an antiplatelet effect
  • Can be given orally with or without food

Interactions

  • Increases risk of bleeding with NSAIDs, warfarin, selective serotonin and serotonin norepinephrine reuptake inhibitors (SSRIs, SNRIs)
  • Avoid concomitant use with CYP2C19 inhibitors (omeprazole or esomeprazole)
  • Increases plasma concentrations of Repaglinide when used concomitantly with Repaglinide

Contraindications

  • Hypersensitivity to the drug substance
  • Hypersensitivity to any component of the product
  • Active pathological bleeding such as peptic ulcer or intracranial hemorrhage

Side Effects

  • Common: Bleeding, Diarrhoea, gastrointestinal discomfort, haemorrhage, Skin reactions
  • Rare: Acquired haemophilia, anaemia, angioedema, arthralgia, arthritis, bone marrow disorders

Pregnancy & Lactation

  • Should be used during pregnancy only if clearly needed
  • Unknown whether clopidogrel is excreted in human breast milk
  • Decision should be made on whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother

Precautions & Warnings

  • Metabolism to active metabolite impaired by genetic variations in CYP2C19
  • Metabolism to active metabolite impaired by drugs that inhibit CYP2C19
  • Inhibition of platelet aggregation for the lifetime of the platelet
  • Increased risk of bleeding
  • Discontinuation increases the risk of cardiovascular events
  • Risk of Thrombotic Thrombocytopenic Purpura (TTP)
  • Risk of hypersensitivity including rash, angioedema, or hematologic reaction
  • Thrombotic Thrombocytopenic Purpura (TTP) reported

Use in Special Populations

  • Safety and effectiveness in pediatric populations not established
  • No dosage adjustment necessary in elderly patients

Overdose Effects

  • May lead to bleeding complications
  • Platelet transfusion may restore clotting ability

Storage Conditions

  • Keep below 30°C temperature
  • Store in a dry place
  • Protected from light
  • Do not freeze
  • Keep out of the reach of children

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