Embelin 5 mg (Tablet)
Unit Price: ৳ 40.00 (2 x 10: ৳ 800.00)
Strip Price: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ambrisentan |
| Company | Incepta pharmaceuticals ltd |
Indications
- Treatment of Pulmonary Arterial Hypertension (PAH)
- Improvement of exercise ability
- Delay of clinical worsening
Pharmacology
- High-affinity ETA receptor antagonist
- Potent autocrine and paracrine peptide
- Vasoconstriction and cell proliferation actions
- Vasodilation and antiproliferation actions
- Substrate of P-gp
- Highly bound to plasma proteins (99%)
- Elimination predominantly by non-renal pathways
Dosage & Administration
- Adult dose: Initial treatment of 5 mg once daily
- Can be increased to 10 mg once daily if 5 mg is tolerated
- Pediatric patient use not established
Interaction
- Co-administration with Cyclosporine results in 2-fold increase in exposure
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients with Idiopathic Pulmonary Fibrosis (IPF)
Side Effects
- Decreases in hemoglobin concentration
- Decreases in hematocrit
Pregnancy & Lactation
- Pregnancy Category X
- Not recommended during breastfeeding
Precautions & Warnings
- Peripheral edema as a known class effect
- Consideration for pulmonary veno-occlusive disease
- Hematological changes observed in clinical studies
- Not recommended in moderate or severe hepatic impairment
Therapeutic Class
- Anti-hypertensive
- Endothelin receptor antagonist
Storage Conditions
- Store below 30°C
- Protect from light and moisture