Tizabet 200 mg (Capsule)

Indications

• Tizabet is indicated for hyperlipidemias of type lla, llb, III, IV & V

Pharmacology

• Fenofibrate is a fibric acid derivative
• Produces reductions in total cholesterol, LDL cholesterol, Apo-lipoprotein B, Total triglycerides and VLDL
• Increases in HDL and apo-proteins apoAI apoAII
• Reduces serum uric acid levels
• Micronised form has enhanced absorption

Dosage & Administration

• Initial dose of Fenofibrate for adult patients with hypercholesterolemia or mixed hyperlipidemia is 200 mg per day
• Initial dose for adult patients with hypertriglyceridemia is 67 to 200 mg per day
• Dose should be individualized according to patient response
• Fenofibrate should be given with meal for optimizing bioavailability

Interaction

• Potentiates the anticoagulant effects of warfarin
• May improve glucose tolerance and have additive effect when administered with antidiabetic drug
• May increase the nephrotoxicity of cyclosporine
• Cautions should be taken against the use with HMG-CoA reductase inhibitors
• Low-dose statins with Tizabet appears to be well tolerated

Contraindications

• Hypersensitivity to Fenofibrate
• Severe renal or hepatic impairment
• Existing gall bladder disease
• Breast feeding mothers
• Photosensitivity to ketoprofen

Side Effects

• Gastro-intestinal issues like nausea, anorexia, gastric pain
• Pruritus, urticaria
• Impotence
• Headache, dizziness, vertigo, fatigue
• Hair loss
• Myotoxicity

Pregnancy & Lactation

• Fenofibrate is not recommended for pregnant women

Precautions & Warnings

• Special care needed in patients with renal disease
• Discontinue if myotoxicity suspected or creatinine kinase concentration increases significantly
• Liver function tests recommended every 3 months for first year

Overdose Effects

• No specific treatment for overdose
• General supportive care indicated
• Hemodialysis not considered due to high binding to plasma proteins

Therapeutic Class

• Fibrates

Storage Conditions

• Do not store above 30°C
• Keep away from light and out of the reach of children

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