Pladex 75 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clopidogrel bisulphate |
| Company | Unimed unihealth pharmaceuticals ltd |
Indications
- Reduction of myocardial infarction and stroke in non-ST-elevation ACS
- Reduction of myocardial infarction and stroke in acute ST-elevation myocardial infarction
- Reduction of myocardial infarction and stroke in established peripheral arterial disease or recent MI/stroke
Pharmacology
- Prodrug
- Inhibition of platelet activation and aggregation
- Irreversible binding of active metabolite to P2Y12 class of ADP receptors
Dosage & Administration
- 300 mg oral loading dose for acute coronary syndrome
- 75 mg once daily orally for recent MI, recent stroke, or established peripheral arterial disease
- Can be given with or without food
Interaction
- Increased risk of bleeding with NSAIDs, warfarin, SSRIs, SNRIs
- Avoid concomitant use of omeprazole or esomeprazole
- Increased plasma concentrations of Repaglinide when used concomitantly
Contraindications
- Hypersensitivity to the drug substance or any component
- Active pathological bleeding such as peptic ulcer or intracranial hemorrhage
Side Effects
- Common: Bleeding, diarrhea, gastrointestinal discomfort, skin reactions
- Rare: Acquired haemophilia, anaemia, angioedema, bone marrow disorders
Pregnancy & Lactation
- Use during pregnancy only if clearly needed
- Unknown excretion in human breast milk, decision on nursing to be made following consideration of drug importance to the mother
Precautions & Warnings
- Impaired metabolism in CYP2C19 poor metabolizers and with drugs that inhibit CYP2C19
- Increased risk of bleeding due to lifetime platelet aggregation inhibition
- Discontinuation increases risk of cardiovascular events, TTP has been reported
Use in Special Populations
- Safety and effectiveness in pediatric populations not established
- No dosage adjustment necessary in elderly patients
Overdose Effects
- May lead to bleeding complications, platelet transfusion may restore clotting ability
Therapeutic Class
- Anti-platelet drugs
Storage Conditions
- Keep below 30°C in a dry place
- Protected from light
- Do not freeze
- Keep out of the reach of children