Esodip 2.5 mg (Tablet)
Unit Price: ৳ 7.00 (2 x 10: ৳ 140.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Levamlodipine maleate |
| Company | Renata limited |
| Also available as | Esodip 125 mg tabletEsodip 5 mg tablet |
Indications
- Treatment of hypertension
- Lowering blood pressure
- Reducing risk of strokes and myocardial infarctions
Pharmacology
- Dihydropyridine calcium antagonist
- Inhibits transmembrane influx of calcium ions
- Selective effect on vascular smooth muscle cells
Absorption
- Oral administration
- Tmax of 6-12 hours
- Bioavailability of 64-90%
Distribution
- Volume of distribution similar to amlodipine
- Volume of distribution of amlodipine is 21 L/kg
Metabolism and Excretion
- 90% metabolized to inactive metabolites
- Primarily metabolized by CYP3A4
- 60% eliminated in urine
Dosage & Administration
- Oral route of administration
- Usual initial dose of 2.5 mg once daily
- Maximum dose of 5 mg once daily
- Dosage adjustment for elderly and hepatically impaired patients
Interaction
- CYP3A inhibitors affect systemic exposure
- Co-administration with simvastatin and immunosuppressants
- Ability to be taken with or without food
- Avoidance of grapefruit products and natural licorice
Contraindications
- Known sensitivity to amlodipine
Side Effects
- Common: Difficulty in breathing, Dizziness, Hypotension
- Rare: Diarrhea, Back pain, Headache
Pregnancy & Lactation
- Limited data on use during pregnancy
- No adverse effects observed on breastfed infant
Precautions & Warnings
- Possibility of symptomatic hypotension
- Potential for worsening angina and myocardial infarction
- Need for slow titration in patients with hepatic impairment
Overdose Effects
- Excessive peripheral vasodilation
- Marked hypotension
- Possibly reflex tachycardia
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Cool and dry place
- Protection from light and moisture