Plagrin 75 mg (Tablet)

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Clopidogrel bisulphate
Company Renata limited

Title

  • Plagrin Tablet 75mg

Categories

  • Medicine
  • Healthcare
  • Pharmaceutical

Description

  • Plagrin Tablet 75mg is indicated for reducing the rate of myocardial infarction (MI) and stroke in patients with acute coronary syndrome, recent MI, recent stroke, or established peripheral arterial disease. It is an antiplatelet drug that inhibits platelet activation and aggregation. The recommended dosage is a 300mg loading dose for acute coronary syndrome and 75mg once daily for other conditions. It should be used with caution in patients with specific interactions and contraindications. Plagrin Tablet 75mg may cause common side effects such as bleeding, diarrhea, and skin reactions.

Color Options

  • N/A

Dimensions

  • N/A

Functions

  • Reduces rate of myocardial infarction and stroke
  • Inhibits platelet activation and aggregation
  • Dose-dependent inhibition of platelet aggregation
  • Indicated for acute coronary syndrome, recent MI, recent stroke, and established peripheral arterial disease

Materials

  • N/A

Technical Specifications

  • Irreversible binding to P2Y12 class of ADP receptors on platelets
  • Dose-dependent inhibition of platelet aggregation in 2 hours after single oral doses
  • Inhibition reaches steady state between Day 3 and Day 7

Design Elements

  • Prodrug

Usability Features

  • Recommended dosage administration orally with or without food
  • No dosage adjustment necessary in elderly patients

Interaction

  • Increases risk of bleeding when used with NSAIDs, warfarin, SSRIs, SNRIs
  • Avoid concomitant use with CYP2C19 inhibitors (omeprazole or esomeprazole)
  • Increases plasma concentrations of Repaglinide when used with it

Contraindications

  • Hypersensitivity to the drug substance or any component of the product
  • Active pathological bleeding such as peptic ulcer or intracranial hemorrhage

Side Effects

  • Common side effects: Bleeding, Diarrhea, Gastrointestinal discomfort, Haemorrhage, Skin reactions
  • Rare side effects: Acquired haemophilia, Anemia, Angioedema, Arthralgia, Arthritis, Bone marrow disorders

Pregnancy & Lactation

  • Use during pregnancy only if clearly needed
  • Unknown excretion in human breast milk, decision should be made whether to discontinue nursing or the drug based on importance to the mother

Precautions & Warnings

  • Metabolism impairment by genetic variations in CYP2C19 and drugs that inhibit CYP2C19
  • Long-term inhibition of platelet aggregation may increase risk of bleeding
  • Discontinuation increases risk of cardiovascular events, discontinue prior to elective surgery with major risk of bleeding

Use in Special Populations

  • Safety and effectiveness in pediatric populations not established

Overdose Effects

  • May lead to bleeding complications, platelet transfusion may restore clotting ability based on biological plausibility

Therapeutic Class

  • Anti-platelet drugs

Storage Conditions

  • Keep below 30°C temperature in a dry place
  • Protected from light
  • Do not freeze
  • Keep out of the reach of children

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