Injefer 100 mg/2 ml (IV Injection or Infusion)

2 ml vial: ৳ 400.00

Medicine Details

Category Details
Generic Ferric carboxymaltose
Company Opsonin pharma ltd
Also available as
Injefer 1 gm injection Injefer 500 mg injection

Title

  • Injefer Colloidal Iron (III) Hydroxide in Complex with Carboxymaltose

Categories

  • Medicine
  • Pharmaceutical Product

Description

  • A colloidal iron (III) hydroxide in complex with Carboxymaltose, a Carbohydrate polymer that releases iron.

Indications

  • Treatment of iron deficiency anaemia in adult patients with intolerance to oral iron or unsatisfactory response to oral iron. Also indicated for non-dialysis dependent chronic kidney disease.

Dosage & Administration

  • Stepwise approach for determination and administration of individual iron need
  • Calculation and administration of the iron dose(s) based on patient's body weight and haemoglobin (Hb) level
  • Post-iron repletion assessments by the clinician

Interaction

  • Formal drug interaction studies have not been performed with Injefer.

Contraindications

  • Hypersensitivity to the active substance, to Ferric Carboxymaltose or any of its excipients
  • Known serious hypersensitivity to other parenteral iron products
  • Anaemia not attributed to iron deficiency
  • Evidence of iron overload or disturbances in the utilisation of iron

Side Effects

  • Common: nausea, headache, dizziness, hypertension, injection site reactions
  • Uncommon: hypersensitivit, dysgeusia, tachycardia, hypotension, flushing, dyspnoea, and more
  • Rare: anaphylactoid reactions, loss of consciousness, anxiety, phlebitis, syncope, and more

Pregnancy & Lactation

  • No adequate and well-controlled trials in pregnant women
  • Use during pregnancy requires careful benefit/risk evaluation
  • Unlikely risk to the breast-fed child

Precautions & Warnings

  • Serious hypersensitivity reactions reported
  • Monitor patients for signs and symptoms of hypersensitivity during and after administration
  • Transiet elevations in systolic blood pressure may occur
  • Laboratory assays may overestimate serum iron and transferrin bound iron

Use in Special Populations

  • Single maximum daily injection dose limitation for haemodialysis-dependent chronic kidney disease patients
  • Not recommended in children under 14 years

Overdose Effects

  • Excessive dosages may lead to accumulation of iron in storage sites potentially leading to hemosiderosis
  • Monitoring of iron parameters may assist in recognising iron accumulation
  • Treat according to standard medical practice in case of iron accumulation

Therapeutic Class

  • Parenteral Iron Preparations

Storage Conditions

  • Store in a cool (below 30°C) & dry place, away from light. Do not freeze. Keep out of the reach of children.

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