Cordef 24 mg (Tablet)
Unit Price: ৳ 30.00 (2 x 10: ৳ 600.00)
Strip Price: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Deflazacort |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Indications
- Anaphylaxis, asthma, severe hypersensitivity reactions
- Rheumatoid arthritis, juvenile chronic arthritis, polymyalgia rheumatica
- Systemic lupus erythematosus, dermatomyositis, mixed connective tissue disease (other than systemic sclerosis), polyartritis nodosa, sarcoidosis
- Pemphigus, bullous pemphigoid, pyoderma gangrenosum
- Minimal change nephrotic syndrome, acute interstitial nephritis
- Rheumatic carditis
- Ulcerative colitis, Crohn's disease
- Uveitis, optic neuritis
- Autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura
- Acute and lymphatic leukaemia, malignant lymphoma, multiple myeloma
- Immune suppression in transplantation
Pharmacology
- Anti-inflammatory action
- Inhibition of Phospholipase A2 enzyme
- Prostaglandin synthesis inhibition
- Immunosuppressive action
- Decreased release of certain chemicals in the immune system
Dosage & Administration
- Maximum adult dose: 120 mg/day
- Maintenance doses: 3-18 mg/day
- Titration based on clinical need
- Children's dose range: 0.25-1.5 mg/kg/day
- Dose adjustment in renal impairment
- Alternate day administration for children
Interaction
- Metabolized in the liver
- Interaction with liver enzyme inducers
- Potential dose adjustment for liver enzyme inhibitors
Contraindications
- Hypersensitivity to any ingredients
- Patients receiving live virus immunization
Side Effects
- GI disturbances
- Musculoskeletal effects
- Endocrine disturbances
- Neuropsychiatric effects
- Ophthalmic effects
- Fluid and electrolyte disturbances
- Infection susceptibility
- Impaired healing
- Hypersensitivity reactions
- Skin atrophy
- Telangiectasia
- Acne
- Cardiac complications
- Thromboembolism
Pregnancy & Lactation
- Placental transfer of Deflazacort
- Increased risk of intrauterine growth retardation
- Excretion in breast milk
- Potential adrenal suppression in infants
Precautions & Warnings
- Special caution in cardiac disease or congestive heart failure
- Frequent patient monitoring
- Salt and water retention potential
- Need for potassium supplementation
- Precautions in gastritis, oesophagitis, diverticulitis, ulcerative colitis, peptic ulcer
- Caution in diabetes mellitus, osteoporosis, myasthenia gravis
- Monitoring in emotional instability, psychotic tendency, epilepsy
- Risk of corticosteroid-induced myopathy
- Special caution in liver failure, hypothyroidism, cirrhosis
- Ocular herpes simplex precautions
Use in Special Populations
- Dose monitoring in hepatic impairment
- No special precautions in renal impairment
- No special precautions in elderly patients
- Serious consequences in old age
Therapeutic Class
- Glucocorticoids
Storage Conditions
- Cool and dry storage (below 25°C)
- Protection from light and moisture
- Keep out of reach of children