Clix 125 mg/5 ml (Powder for Suspension)

60 ml bottle: ৳ 395.00

Medicine Details

Category Details
Generic Clarithromycin
Company Eskayef pharmaceuticals ltd
Also available as
Clix 500 mg tablet

Indications

  • Acute bacterial exacerbation of chronic bronchitis in adults
  • Acute maxillary sinusitis
  • Community-acquired pneumonia
  • Pharyngitis or tonsillitis
  • Uncomplicated skin and skin structure infections
  • Acute otitis media in pediatric patients
  • Treatment and prophylaxis of disseminated mycobacterial infections
  • Helicobacter pylori infection and duodenal ulcer disease in adults

Pharmacology

  • Inhibits microsomal protein synthesis
  • Binds to 50S subunit of bacterial ribosome
  • Active against most Gram-positive bacteria
  • More acid-stable than Erythromycin
  • Twice the activity of Erythromycin against H. influenzae
  • Inactivity against most species of Gram-negative bacteria

Dosage & Administration

  • Dosage for adults
  • Combination dosing regimens for H. pylori infection
  • Dosage for children
  • Dosage for renal and hepatic impairment

Interaction

  • Contraindicated with specific medications

Contraindications

  • Known hypersensitivity to clarithromycin or macrolide antibacterial drugs
  • History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin

Side Effects

  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Stomatitis
  • Glossitis
  • Headache
  • Allergic reactions
  • Taste perversion
  • Transient central nervous system side effects

Pregnancy & Lactation

  • Use in neonates and children
  • Avoid giving breast milk to infants
  • Not recommended in pregnant patients

Precautions & Warnings

  • Discontinue if severe acute hypersensitivity reactions occur
  • Avoid in patients with known QT prolongation or receiving drugs known to prolong the QT interval
  • Increased risk of all-cause mortality in patients with coronary artery disease
  • Evaluate for Clostridium difficile associated diarrhea if diarrhea occurs

Use in Special Populations

  • Safety and effectiveness in pediatric patients
  • Safety and effectiveness for prevention of disseminated Mycobacterium avium complex (MAC) disease in pediatric patients with advanced HIV infection

Overdose Effects

  • Expected gastro-intestinal symptoms
  • Prompt elimination of unabsorbed drug and supportive measures

Therapeutic Class

  • Macrolides

Storage Conditions

  • Store in a cool and dry place
  • Reconstituted suspension must be used within specified days
  • Keep out of reach of children

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