Clix 125 mg/5 ml (Powder for Suspension)
60 ml bottle: ৳ 395.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Acute bacterial exacerbation of chronic bronchitis in adults
- Acute maxillary sinusitis
- Community-acquired pneumonia
- Pharyngitis or tonsillitis
- Uncomplicated skin and skin structure infections
- Acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibits microsomal protein synthesis
- Binds to 50S subunit of bacterial ribosome
- Active against most Gram-positive bacteria
- More acid-stable than Erythromycin
- Twice the activity of Erythromycin against H. influenzae
- Inactivity against most species of Gram-negative bacteria
Dosage & Administration
- Dosage for adults
- Combination dosing regimens for H. pylori infection
- Dosage for children
- Dosage for renal and hepatic impairment
Interaction
- Contraindicated with specific medications
Contraindications
- Known hypersensitivity to clarithromycin or macrolide antibacterial drugs
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient central nervous system side effects
Pregnancy & Lactation
- Use in neonates and children
- Avoid giving breast milk to infants
- Not recommended in pregnant patients
Precautions & Warnings
- Discontinue if severe acute hypersensitivity reactions occur
- Avoid in patients with known QT prolongation or receiving drugs known to prolong the QT interval
- Increased risk of all-cause mortality in patients with coronary artery disease
- Evaluate for Clostridium difficile associated diarrhea if diarrhea occurs
Use in Special Populations
- Safety and effectiveness in pediatric patients
- Safety and effectiveness for prevention of disseminated Mycobacterium avium complex (MAC) disease in pediatric patients with advanced HIV infection
Overdose Effects
- Expected gastro-intestinal symptoms
- Prompt elimination of unabsorbed drug and supportive measures
Therapeutic Class
- Macrolides
Storage Conditions
- Store in a cool and dry place
- Reconstituted suspension must be used within specified days
- Keep out of reach of children