Dasatab 20 mg (Tablet)

Unit Price: ৳ 80.00 (3 x 10: ৳ 2,400.00)
Strip Price: ৳ 800.00

Medicine Details

Category Details
Generic Dasatinib
Company Eskayef pharmaceuticals ltd
Also available as
Dasatab 100 mg tablet

Indications

  • Treatment of chronic myeloid leukemia (CML) in chronic phase
  • Treatment of CML in accelerated phase or myeloid or lymphoid blast phase with resistance or intolerance to prior therapy
  • Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL) with resistance or intolerance to prior therapy
  • Treatment of pediatric patients 1 year of age and older with Ph+ CML in chronic phase
  • Treatment of newly diagnosed Ph+ ALL in combination with chemotherapy

Pharmacology

  • Inhibition of BCR-ABL, SRC family, c-KIT, EPHA2, PDGFRβ
  • In vitro activity against leukemic cell lines
  • Absorption between 0.5 to 6 hours after oral administration
  • Distribution: apparent volume of distribution is 2505 (CV% 93%)
  • Binding to human plasma proteins approximately 96%
  • Metabolism involving CYP3A4, FMO-3, and UGT enzymes
  • Excretion primarily via feces

Dosage & Administration

  • Recommended starting dosage for chronic phase CML in adults: 100 mg once daily
  • Recommended starting dosage for accelerated phase CML, myeloid or lymphoid blast phase CML, or Ph+ ALL in adults: 140 mg once daily
  • Dosage for pediatric patients based on body weight
  • Administration with or without food

Interaction

  • Avoid concomitant use with strong CYP3A4 inhibitors
  • Consider dose reduction with strong CYP3A4 inhibitors
  • Consider dose increase with strong CYP3A4 inducers
  • Avoid administration with gastric acid reducing agents

Contraindications

  • Hypersensitivity to Dasatinib or any component of the formulation

Side Effects

  • Myelosuppression
  • Bleeding-related events
  • Fluid retention
  • Cardiovascular events
  • Pulmonary arterial hypertension
  • QT prolongation
  • Severe dermatologic reactions
  • Tumor lysis syndrome
  • Effects on growth and development in pediatric patients

Pregnancy & Lactation

  • Potential fetal harm
  • Recommendation to avoid pregnancy during treatment
  • Breastfeeding not recommended during treatment

Precautions & Warnings

  • Severe thrombocytopenia, neutropenia, and anemia
  • Serious and fatal bleeding
  • Fluid retention management
  • Monitoring for cardiac dysfunction
  • Risk of pulmonary arterial hypertension
  • Risk of QT prolongation
  • Severe mucocutaneous dermatologic reactions
  • Tumor lysis syndrome monitoring

Overdose Effects

  • Limited clinical study experience
  • Severe myelosuppression and bleeding reported in high overdosage cases

Therapeutic Class

  • Targeted Cancer Therapy

Storage Conditions

  • Store below 30°C in a dry place
  • Protect from light
  • Keep out of the reach of children

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