Navix 75 mg (Tablet)

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Clopidogrel bisulphate
Company Navana pharmaceuticals ltd

Indications

  • Reduces the rate of myocardial infarction (MI)
  • Reduces the rate of stroke
  • Treatment for non-ST-segment elevation ACS
  • Treatment for ST-elevation myocardial infarction (STEMI)
  • Reduces the rate of MI in patients with recent MI or established peripheral arterial disease
  • Reduces the rate of stroke in patients with recent stroke or established peripheral arterial disease

Pharmacology

  • Prodrug
  • Inhibits platelet activation and aggregation
  • Irreversible binding to P2Y12 class of ADP receptors on platelets
  • Dose-dependent inhibition of platelet aggregation
  • Inhibition of platelet aggregation within 2 hours after single oral doses
  • Steady state inhibition reached between Day 3 and Day 7 with repeated 75 mg per day doses

Dosage & Administration

  • 300 mg oral loading dose for patients needing antiplatelet effect within hours
  • 75 mg once daily orally for patients with recent MI, recent stroke, or established peripheral arterial disease
  • Orally administered with or without food

Interaction

  • Increases risk of bleeding when used with NSAIDs, warfarin, SSRIs, SNRIs
  • Avoid concomitant use with CYP2C19 inhibitors such as omeprazole or esomeprazole
  • Increases plasma concentrations of Repaglinide when used concomitantly

Contraindications

  • Hypersensitivity to the drug substance or any component of the product
  • Active pathological bleeding such as peptic ulcer or intracranial hemorrhage

Side Effects

  • Common: Bleeding, Diarrhoea, gastrointestinal discomfort, haemorrhage, Skin reactions
  • Rare: Acquired haemophilia, anaemia, angioedema, arthralgia, arthritis, bone marrow disorders

Pregnancy & Lactation

  • Use during pregnancy only if clearly needed
  • Unknown excretion of clopidogrel in human breast milk
  • Consideration of importance of the drug to the mother when deciding whether to discontinue nursing

Precautions & Warnings

  • Metabolism impairment by genetic variations in CYP2C19 and by drugs that inhibit CYP2C19
  • Increased risk of bleeding due to lifetime inhibition of platelet aggregation
  • Increased risk of cardiovascular events upon discontinuation
  • Reported cases of Thrombotic Thrombocytopenic Purpura (TTP) requiring urgent treatment
  • Reported cases of hypersensitivity reactions including rash, angioedema or hematologic reaction
  • No dosage adjustment necessary in elderly patients

Use in Special Populations

  • Safety and effectiveness not established in pediatric populations

Overdose Effects

  • May lead to bleeding complications
  • Platelet transfusion may restore clotting ability based on biological plausibility

Therapeutic Class

  • Anti-platelet drugs

Storage Conditions

  • Keep below 30°C temperature in a dry place
  • Protected from light
  • Do not freeze
  • Keep out of the reach of children

Related Brands