Glims M XR 1 mg+500 mg (Tablet (Extended Release))

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Glimepiride metformin
Company Opsonin pharma ltd
Also available as
Glims m xr 2 mg tablet

Title

  • Glimepiride and Metformin Tablet

Categories

  • Oral Antidiabetic Medication
  • Combination Therapy
  • Type 2 Diabetes Mellitus

Description

  • This tablet is indicated as an adjunct to diet and exercise in type 2 diabetes mellitus patients.
  • Primary mechanism of action depends on stimulating insulin release from pancreatic beta cells.

Color Options

  • N/A

Active Ingredients

  • Glimepiride
  • Metformin Hydrochloride

Dosage Form

  • Tablet

Dosage Strengths

  • Various strengths available, maximum recommended dose 8mg glimepiride and 2000mg metformin daily

Packaging

  • Blister Pack
  • Bottle

Dosage Instructions

  • Dosage is governed by desired blood glucose level
  • Avoid correcting missed doses by taking a larger dose
  • Glimepiride requirements may decrease with improved diabetes control
  • Starting dose should not exceed current daily doses of glimepiride or metformin

Administration

  • Tablets must be swallowed whole, not crushed or chewed

Interaction

  • Metabolized by cytochrome P450 2C9, consider when coadministered with CYP2C9 inducers or inhibitors
  • Potential interactions with various drugs such as insulin, ACE inhibitors, corticosteroids, diuretics, etc.
  • Alcohol intake may affect blood-glucose-lowering action in unpredictable ways

Contraindications

  • Hypersensitivity to glimepiride, metformin, sulfonylureas, sulfonamides, or any excipients
  • Pregnancy, breastfeeding
  • Severe impairment of liver and renal function

Side Effects

  • Hypoglycemia
  • Temporary visual impairment
  • Gastrointestinal symptoms
  • Hepatitis, elevation of liver enzyme levels
  • Alopecia
  • Allergic reactions
  • Weight gain (for glimepiride)
  • Gastrointestinal symptoms, metallic taste (for metformin)
  • Decrease of vitamin B12 absorption, lactic acidosis, hemolytic anemia, hepatobiliary disorders (for metformin)

Pregnancy & Lactation

  • Glimepiride and metformin not recommended during pregnancy, insulin preferred
  • Metformin excreted into milk, decision on nursing should consider benefit to the mother

Precautions & Warnings

  • Increased risk of hypoglycemia in initial weeks of treatment
  • Caution in patients with G6PD-deficiency
  • Regular monitoring of thyroid-stimulating hormone levels recommended for hypothyroidism
  • Long-term treatment associated with decrease in vitamin B12 serum levels, monitor B12 levels
  • Assess renal function before initiation and annually thereafter

Special Populations

  • Insufficient data for pediatric use
  • Assessment of GFR required before initiation of treatment with metformin-containing products

Overdose Effects

  • Acute overdosage may lead to severe life-threatening hypoglycemia
  • Hypoglycemia not seen with metformin doses up to 85g, but lactic acidosis can occur

Therapeutic Class

  • Combination oral hypoglycemic preparations

Storage Conditions

  • Store in a cool, dry place, protected from light

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