LM 2.5 mg (Tablet)
Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Levamlodipine maleate |
| Company | Acme laboratories ltd |
| Also available as | Lm 5 mg tablet |
Therapeutic Class
- Calcium-channel blockers
Indications
- Treatment of hypertension
- Lowering blood pressure
- Reducing risk of fatal and nonfatal cardiovascular events
Pharmacology
- Dihydropyridine calcium antagonist
- Inhibition of transmembrane influx of calcium ions
- Selective effect on vascular smooth muscle cells
Absorption
- Tmax of 6-12 hours
- Bioavailability of 64-90%
- Not significantly affected by food
Distribution
- Volume of distribution similar to amlodipine
- Volume of distribution of amlodipine: 21 L/kg
Metabolism and Excretion
- 90% metabolized to inactive metabolites
- Metabolism primarily mediated by CYP3A4
- 60% eliminated in urine
Dosage & Administration
- Oral route of administration
- Usual initial dose: 2.5 mg once daily
- Maximum dose: 5 mg once daily
- Pediatric dose: 1.25-2.5 mg once daily
- Dosage adjustment for elderly and hepatically impaired patients
Interaction
- Impact of CYP3A Inhibitors
- Impact of CYP3A Inducers
- Co-administration with simvastatin
- Impact on immunosuppressants
- Can be taken with or without food
- Avoid grapefruit products & natural licorice
Contraindications
- Known sensitivity to amlodipine
Side Effects
- Common: Difficulty in breathing, Dizziness, Reflex Tachycardia, Hypotension, Abdominal Pain & Edema
- Rare: Diarrhea, Back pain, Headache, Fatigue, Nausea
Pregnancy & Lactation
- Limited data on use during pregnancy
- No adverse effects on breastfed infants
Precautions & Warnings
- Possibility of symptomatic hypotension
- Risk of increased angina or myocardial infarction
- Special considerations for patients with hepatic failure
Overdose Effects
- Expected effects: excessive peripheral vasodilation, marked hypotension, reflex tachycardia
Storage Conditions
- Cool & dry storage
- Protection from light & moisture
- Keep out of reach of children