LM 5 mg (Tablet)

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Levamlodipine maleate
Company Acme laboratories ltd
Also available asLm 25 mg tablet

Therapeutic Class

  • Calcium-channel blockers

Indications

  • Treatment of hypertension
  • Lowering blood pressure
  • Reducing risk of cardiovascular events

Mode of Action

  • Dihydropyridine calcium antagonist
  • Inhibits transmembrane influx of calcium ions
  • Selective effect on vascular smooth muscle cells
  • Pharmacologically active isomer: Levamlodipine

Dosage & Administration

  • Oral route of administration
  • Usual initial dose: 2.5 mg once daily
  • Maximum dose: 5 mg once daily
  • Elderly and hepatically impaired patients: 1.25 mg once daily
  • Pediatric dose: 1.25-2.5 mg once daily

Interaction

  • Impact of CYP3A inhibitors on amlodipine
  • Impact of amlodipine on simvastatin
  • Impact of amlodipine on immunosuppressants
  • Can be taken with or without food
  • Avoid grapefruit products & natural licorice

Contraindications

  • Known sensitivity to amlodipine

Side Effects

  • Common: Difficulty in breathing, Dizziness, Reflex Tachycardia, Hypotension, Abdominal Pain, Edema
  • Rare: Diarrhea, Back pain, Headache, Fatigue, Nausea

Pregnancy & Lactation

  • Limited data on use in pregnant women
  • No adverse effects observed on breastfed infants

Precautions & Warnings

  • Possible symptomatic hypotension
  • Risk of increased angina or myocardial infarction
  • Slow titration for hepatically impaired patients

Overdose Effects

  • Excessive peripheral vasodilation
  • Marked hypotension
  • Possibly reflex tachycardia

Storage Conditions

  • Cool & dry place
  • Protection from light & moisture
  • Keep out of reach of children

Absorption

  • Tmax: 6-12 h
  • Bioavailability: 64-90%
  • Not significantly affected by food

Distribution

  • Volume of distribution similar to amlodipine
  • Amlodipine volume of distribution: 21 L/kg

Metabolism and Excretion

  • 90% metabolized to inactive metabolites
  • Primarily metabolized by CYP3A4
  • 60% eliminated in urine

Route of Administration

  • Oral

Hypotension

  • Symptomatic hypotension possible

Obstructive Coronary Artery Disease

  • Increased risk of worsening angina or myocardial infarction

Liver Metabolism

  • Extensively metabolized by the liver
  • Plasma elimination half-life: 56 hours in hepatically impaired patients

Overdose

  • Excessive vasodilation
  • Marked hypotension
  • Reflex tachycardia

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