Emlino 10 mg+5 mg (Tablet)

Unit Price: ৳ 30.00 (3 x 10: ৳ 900.00)
Strip Price: ৳ 300.00

Medicine Details

Category Details
Generic Empagliflozin linagliptin
Company Acme laboratories ltd
Also available as
Emlino 25 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control
  • Type 2 diabetes mellitus

Pharmacology

  • Inhibits DPP-4 enzyme
  • Increases active incretin hormones
  • Stimulates insulin release
  • Decreases glucagon levels
  • Inhibitor of Sodium-glucose co-transporter 2 (SGLT2)
  • Reduces renal reabsorption of glucose
  • Increases urinary glucose excretion

Dosage & Administration

  • Recommended dose: 10 mg Empagliflozin and 5 mg Linagliptin once daily
  • Increased dose: 25 mg Empagliflozin and 5 mg Linagliptin once daily
  • Assess renal function before initiating
  • Do not initiate if eGFR is below 45 mL/min/1.73 m2
  • Renal impaired patients

Interaction

  • Diuretics
  • Insulin or Insulin Secretagogues
  • Inducers of P-glycoprotein or CYP3A4 Enzymes
  • Positive Urine Glucose Test
  • Interference with 1,5-anhydroglucitol (1,5-AG) Assay

Contraindications

  • Severe renal impairment
  • End-stage renal disease or dialysis
  • Hypersensitivity reaction to Linagliptin
  • Serious hypersensitivity reaction to Empagliflozin

Side Effects

  • Pancreatitis
  • Ketoacidosis
  • Volume Depletion
  • Urosepsis and Pyelonephritis
  • Hypoglycemia with Concomitant Use with Insulin and Insulin Secretagogues
  • Necrotizing Fasciitis of the Perineum (Fournier’s Gangrene)
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • Severe and Disabling Arthralgia
  • Bullous Pemphigoid
  • Heart Failure

Pregnancy & Lactation

  • Not recommended during the second and third trimesters of pregnancy
  • Limited available data in pregnant women
  • Risks to mother and fetus due to poorly controlled diabetes in pregnancy

Precautions & Warnings

  • Pancreatitis
  • Hypotension
  • Ketoacidosis
  • Acute kidney injury and impairment in renal function
  • Urosepsis and Pyelonephritis
  • Hypoglycemia
  • Genital Mycotic Infections
  • Hypersensitivity
  • Necrotizing Fasciitis of the Perineum (Fournier’s Gangrene)
  • Heart Failure association with DPP-4 inhibitor treatment

Overdose Effects

  • Contact Poison Control Center
  • Supportive measures
  • Removal of unabsorbed material from the gastrointestinal tract

Therapeutic Class

  • Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Storage Conditions

  • Store below 30° C temperature
  • Keep away from light and wet place
  • Keep out of reach of children

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