Maximox 400 mg/250 ml (IV Infusion)

Indications

• Acute Bacterial Sinusitis
• Acute Bacterial Exacerbation of Chronic Bronchitis
• Community Acquired Pneumonia
• Skin and Skin Structure Infections: Uncomplicated and Complicated
• Complicated Intra-Abdominal Infections

Dosage

• 400 mg once daily for Acute Bacterial Sinusitis for 10 days
• 400 mg once daily for Acute Bacterial Exacerbation of Chronic Bronchitis for 5 days
• 400 mg once daily for Community Acquired Pneumonia for 7-14 days
• 400 mg once daily for Uncomplicated Skin and Skin Structure Infections for 7 days
• 400 mg once daily for Complicated Skin and Skin Structure Infections for 7-21 days
• 400 mg once daily for Complicated Intra-Abdominal Infections for 5-14 days

Administration

• Intravenous infusion over a period of 60 minutes
• Check the bag for minute leaks by squeezing the inner bag firmly
• Do not use if the solution is cloudy or a precipitate is present
• Do not use flexible bags in series connections
• Close flow control clamp of administration set
• Remove cover from port at bottom of bag
• Insert piercing pin of administration set into port with a twisting motion until the pin is firmly seated
• Suspend bag from hanger
• Squeeze and release drip chamber to establish proper fluid level in chamber during infusion
• Open flow control clamp to expel air from set
• Regulate the rate of administration with flow control clamp

Interaction

• No interaction with oral antacids, sucralfate, multivitamins, didanosine, or metal cations
• No co-administration with any solution containing multivalent cations, e.g., magnesium, through the same intravenous line
• Enhanced anticoagulant effects with warfarin or its derivatives
• Potential for increased risks of CNS stimulation and convulsions when combined with a nonsteroidal anti-inflammatory drug
• Potential for pharmacodynamic interaction with drugs that prolong the QTc interval of the electrocardiogram

Contraindications

• Known hypersensitivity to Moxifloxacin or other quinolone antibacterials

Side Effects

• Common side effects: headache, nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, dizziness, pyrexia, insomnia
• Less common side effects: neutropenia, palpitations, tachycardia, bradycardia, vertigo, tinnitus, dry mouth, gastritis, edema, fatigue, malaise, hyperglycemia, anorexia, hyperlipidemia, hypoglycemia, dehydration, back pain, arthralgia

Pregnancy & Lactation

• Pregnancy Category C
• Excretion in breast milk of rats and potentially in human milk
• Consideration for discontinuation of nursing

Precautions & Warnings

• Increased risk of tendinitis and tendon rupture
• Exacerbation of muscle weakness in persons with myasthenia gravis
• Risk of Clostridium difficile-associated diarrhea (CDAD)

Use in Special Populations

• Safety and effectiveness not established in pediatric patients and adolescents less than 18 years of age
• Increased risk for severe tendon disorders in geriatric patients

Therapeutic Class

• 4-Quinolone preparations

Storage Conditions

• Store below 25°C and protect from light
• Avoid extreme heat and freezing
• Keep out of reach of children

Related Brands

• Eramox 400 mg/250 ml (IV Infusion) - beacon-pharmaceuticals-plc